Efficacy and safety of amiodarone and metoprolol for treating tachyarrhythmia: a Meta-analysis
ZHANG Wenyan
HU Gangying
CHEN Suqin
Abstract：Objective To evaluate the efficacy and safety of amiodarone combined with metoprolol in the treatment of tachyarrhythmia.Methods Collecting the randomized controlled trials (RCT) about metoprolol and amiodarone alone on the treatment of tachyarrhythmia.The quality evaluation was performed using the scale developed by the Jadad improvement method.The extracted data was analyzed by RevMan 5.3 software.Results The results were included 9 papers according to the standard.The results of meta-analysis showed that the total effective rate of amiodarone combined with metoprolol in the treatment of tachyarrhythmia was higher than that of amiodarone alone (OR =7.98,95％ CI 4.64 to 13.70,P ＜ 0.01);the heart rate was lower than that of amiodarone alone (SMD =-22.01,95％ CI-27.20 to-16.81,P ＜0.01) and systolic blood pressure after treatment was lower than that of amiodarone alone (SMD =-24.23,95％ CI-26.04 to-22.43,P ＜ 0.01).Mter treatment,the diastolic blood pressure was lower than that of amiodarone alone group (SMD =-13.62,95％ CI-15.25 to-12.00,P ＜ 0.01).There was no significant difference in the overall incidence of adverse reactions after treatment (OR =0.83,95％ CI 0.44 to 1.59,P =0.58).Conclusion Amiodarone combined with metoprolol group can improve the total effective rate of rapid arthythmia treatment.After treatment,heart rate,systolic blood pressure and diastolic blood pressure are lower than amiodarone alone group,and it will not increase its toxic and side effects.
Keywords：AmiodaroneMetoprololTachyarrhythmiaMeta-analysisRandomized controlled trial
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1141-1144 )