The effect of remote ischemia postconditioning on fluctuation of serum microRNA-21 and microRNA-24 in patients with acute cerebral infarction following intravenous thrombolysis
FAN Jia
ZHA Junjie
QIAN Lina
XU Chunyang
Abstract：Objective To evaluate the effect of remote ischemia post conditioning (RIPC) on fluctuation of serum microRNA-21 and microRNA-24 in patients with acute cerebral infarction (ACI) following intravenous thrombolysis (IT).Methods Sixty-four ACI patients were enrolled in this study and divided into two groups:RIPC group and control group.The patients in control group were giving IT combining normal cerebral infarction treatment.On that basis,the patients in RIPC group were receiving RIPC.The levels of serum miRNA (miR-21 and miR-24) and neurological assessment (NIHSS and Barthel) were measured on four points:before IT (T0),24h (T1),1 week (T2) and 2 week (T3) after IT.Results The levels of serum miR-2i were significantly reduced after treatment in both RIPC group and control group (RIPC group:F =3.178,P =0.019;control group:F =3.519,P =0.012),while levels of miR-24 were significantly increased (RIPC group:F =4.288,P =0.004;control group:F =4.161,P =0.005).On both T2 and T3,the levels of serum miR-21 in RIPC group were lower than those in control group(T2:t =2.446,P =0.020;T3:t =2.557,P =0.016),while levels of serum miR-24 were higher(T2:t =2.394,P =0.002;T3:t =2.597,P =0.014).The levels of NIHSS score were significantly reduced after treatment in both RIPC group and control group (RIPC group:F =3.947,P =0.006;control group:F =3.095,P =0.022),while levels of Barthel score were significantly increased (RIPC group:F =2.669,P =0.040;control group:F =3.521,P =0.012).On both T2 and T3,the levels of NIHSS score in RIPC group were lower than those in control group (T2:t =2.754,P =0.010;T3:t =2.865,P =0.007),while levels of Barthel score were higher (T2:t =2.643,P =0.013;T3:t =2.976,P =0.006).Correlation analysis showed that RIPC + IT was negatively associated with both miR-21 and NIHSS,and positively related with miR-24 and Barthel score,which R value were all higher than those with single IT treatment.Conclusion The RIPC may increase the neurological recovery in ACI patients following IT treatment,which may be associated with the mediating of miR-21 and miR-24.
Keywords：Remote ischemia postconditioningCerebral infarctionacutemicroRNA-21microRNA-24
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1085-1088,1092 )