Expression of P53 and MDM-2 in lung cancer and its correlation with clinicopathological features of lung cancer
WANG Zhengjiang
WANG Dexia
DOU Huihui
WANG Juan
Abstract：Objective To investigate the expression of P53 and MDM-2 in lung cancer,and to analyze the association between P53,MDM-2 and clinicopathological features of lung cancer.Methods Seventy-four cases of lung cancer tissues and para-cancerous tissues were collected from January 2014 to December 2016 in our hospital.Immunohistochemistry was used to detect the expression of P53 and MDM-2 protein,and the expression of P53 and MDM-2 in lung cancer tissues and adjacent tissues were analyzed.The correlation between P53,MDM-2 and clinicopathological features of lung cancer was analyzed.Results The positive rate of P53 in lung cancer tissues was significantly higher than that in adjacent tissues(60.8％ vs.18.9％,χ2=26.30,P=0.000);The positive rate of MDM-2 in lung cancer tissues was significantly higher than that in adjacent tissues(48.6％ vs.20.3％,χ2=11.68,P=0.000);The positive rate of P53 in patients with lymph node metastasis was significantly higher than that without lymph node metastasis(χ2=5.462,P=0.019);The positive rate of MDM-2 in patients with lymph node metastasis was significantly higher than that without lymph node metastasis(χ2=6.058,P=0.020);The positive rate of MDM-2 in patients with ≥3cm tumor size was significantly higher than that <3 cm tumor size(χ2=4.710,P=0.041);The positive rate of MDM-2 was statistically different in different stages(χ2=4.689,P=0.034).Conclusion MDM-2 and P53 are highly expressed in non-small cell lung cancer,and the expression level is associated with clinical symptoms,which is involved in the occurrence,growth,invasion and lymph node metastasis of non-small cell lung cancer.
Keywords：P53MDM-2Lung cancerCorrelation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1047-1049,1053 )