The effects of cyclophosphamide combined prednisone on patients with systemic lupus erythematosus
QI Mi
ZHOU Kejin
WANG Shiyu
LI Guochao
Abstract：Objective To observe the effect of prednisone combined with cyclophosphamide in patients with systemic lupus erythematosus interferon and interleukin.Methods From May 2012 to May 2016,in Sichuan Ganzi Tibetan Autonomous Prefecture People's Hospital,86 cases of inpatients in the treatment of systemic lupus erythematosus enrolled as the research object,they were randomly divided into control group (43 cases) and observation group (43 cases),the control group was given prednisone treatment,the observation group based on control group therapy,also used of cyclophosphamide,compared 2 groups of therapeutic effect of interferon and interleukin.Results The total effective rate of observation group was 93.02％,which was higher than 76.74％ in the control group(χ2=4.440,P=0.035);after treatment,the observation group of patients' IgA,IgG,IgM levels lower than the control group,C3,C4 levels higher than the control group,the differences were statistically significant (t=3.374,P=0.001;t=5.966,P=0.000;t=3.013,P=0.004);After treatment,IL-6,IL-10,IFN-α levels decreased,compared 2 groups of IL-6,IL-10 and IFN-α levels after treatment,the difference was statistically significant (t=6.779,P=0.000;t=4.734,P=0.000;t=7.990,P=0.000).Conclusion Cyclophosphamide combined with prednisone can improve the treatment effect greatly,and reduce the level of INF-α,IL-6,IL-10.
Keywords：Systemic lupus erythematosusInterferon αInterleukinCyclophosphamidePrednisone
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1021-1024 )