The application of 1H MRS in Parkinson's disease

JIANG Mingfang; NIU Guangming; SHI Feng; GAO Yang; XIE Shenghui

doi:10.3969/j.issn.1671-6450.2017.10.010

Abstract：Objective To investigate the clinical value of 1H MRS in the diagnosis of Parkinson's disease.Methods Thirty-one patients with Parkinson's disease and 34 healthy control performed conventional MRI and 1H MRS imaging.Then measured the levels of N acetyl compounds (NAA),creatine (Cr) and choline compounds (Cho) in nigra and red nucleus in all patients and healthy subjects by 1H MRS examination.And compared NAA / Cr,NAA / Cho and Cho / Cr ratios between the patient group and healthy control group and analyzed the relationship of the ratios the MoCA,HAMD,ADL and UPDRSIII scores of all PD patients.Results In the study of 1H MRS,NAA / Cr values and NAA / Cho values between the both sides of nigra,the NAA / Cr values and NAA / Cho values between both sides of red nucleus in the patient group were significantly different (P<0.05).According to the ADL scores,HAMD scores and MOCA scores,the patients with PD were divided into three or four groups.The NAA / Cr value and Cho / Cr values in the right substantia nigra between patients with mild depression,moderate depression and without depression were significantly different (P<0.05).The NAA / Cho values in the right substantia nigra were significantly different among different groups according with MoCA scores (P<0.05).Moreover,there was correlation of H Y grade in PD patients with the NAA / Cho values in the right red nucleus,their HAMD scores with NAA/Cr values in the right nigra,the NAA / Cr values in the left substantia nigra,and Cho / Cr values in the right nigra,and MOCA scores with the NAA / Cho values in right substantia nigra.Conclusion 1H MRS cannot be the diagnostic criteria of PD,but show a positive role in the study of depression and cognitive about Parkinson's disease.