The value of serum mannose binding lectin in the early diagnosis of diabetic nephropathy
ZHANG Yafen
CHEN Jing
CHEN Cheng
ZHANG Jing
LU Kuiying
Abstract：Objective To estimate the early diagnosis value of serum mannose binding lectin (MBL) to diabetic kidney disease (DKD) in patients with type 2 diabetes.Methods Fifty DKD patients,fifty diabetes mellitus (DM) patients and fifty non DM patients were enrolled in this study,they were divided into DKD group (n=50),DM group (n=50) and non DM group (n=50),respectively.The difference of serum MBL and sICAM-1 were compared among these three groups.Results The levels of MBL (F=5.418,P=0.002),sICAM-1 (F=4.242,P=0.007) and hs-CRP (F=3.049,P=0.031) in DKD group were higher than those in DM group and control group.ROC analysis showed that the AUC of MBL for DKD was 0.819,which cut-off value was 3 271.5 μg/L with 85.0％ of specificity and 82.0％ of sensitivity.Correlation analysis showed that MBL was positively related with DKD and HbA1c.Logistic regression suggested that sICAM-1 and MBL were independent risk factor for DKD.Conclusion It demonstrated that the serum levels of MBL was elevated in DKD patients,suggested it was potential risk factors.
Keywords：Diabetic kidney diseaseMannose binding lectinEarly diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 997-1000 )