Effect of metoprolol sustained release tablet on inflammatory factor and cardiac function in patients with chronic heart failure
LU Ming
JIANG Qingyuan
LIU Chunlan
LIU Yingying
LIN Jia
KAN Lihong
ZHUNG Xiaohua
CAI Zhenrong
Abstract：Objectives To investigate the influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure.Methods From January 2015 to December 2015,a total of 120 CHF patients in New York Heart Association (NYHA) functional classes II to IV were enrolled and randomized divided into treatment group (n=60) and control group (n=60).All the patients were in stable situation after conventional drug treatment.The patients in treatment group underwent intensive heart rate control for target HR (55-60 bpm) through adjusting the dose of metoprolol sustained release tablets.The resting heart rate was measured at the beginning,1 month and 12 months after treatment.The concentration of C reaction protein (CRP),interleukin 1β(IL-1β),interleukin 6 (IL-6),tumor necrosis factorα(TNF-α) were detected before and after 1 month treatment.The concentration of brain natriuretic peptide (BNP),left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular end systolic dimension (LVESD) was measured before and 12 months after treatment.Results After 1 month treatment,the resting heart rate and inflammatory factors (CRP,IL-1β,IL-6,TNF-α) levels of the patients in the treatment group decreased significantly compared with that of control group (t=2.07,t=2.26,t=1.99,t=2.03,t=2.14,P<0.05).After 12 months treatment,the resting heart rate of the patients in the treatment group decreased significantly compared with that of control group (t=4.22,P<0.01),the echocardiography parameters (LVEDD,LVESD) and the concentration of BNP of the patients in the treatment group decreased significantly (t=2.32,t=2.43,t=2.21,t=2.12,P<0.05),LVEF of treatment group increased significantly (P<0.05).Conclusion Metoprolol sustained release tablets can significantly decrease inflammatory factors (CRP,IL-1β,IL-6,TNF-α) levels and improve cardiac function in patients with chronic heart failure.
Keywords：MetoprololHeart failurechronicInflammatory factorBrain natriuretic peptideCardiac function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 977-980,984 )