Effect of mechanical external cardiac compression in cardiac arrest patients and its influence on cardiac and brain function damage

LIU Zhiqiang; MI Wei; ZHOU Xue; DENG Xigeng

doi:10.3969/j.issn.1671-6450.2017.09.014

Abstract：Objective To observe the effectiveness of mechanical chest compressions in the treatment of cardiac arrest and its effects on cardiac and cerebral function injuries.Methods From May 2014 to July 2016, in the 452 Air Force Hospital emergency department, 119 patients for treatment of cardiac arrest enrolled as the research object, 59 cases received chest compressions enrolled as control group, 60 cases received mechanical chest compressions as observation group.The rescue effects of the 2 groups were evaluated.The levels of myocardial enzymes in peripheral blood and the indexes of serum nerve function damage in patients with survival were measured.Results By different ways after the rescue, the observation group of spontaneous circulation recovery time shorter than the control group (t =9.23, P =0.00), the first phase of recovery of spontaneous heart rate duration was longer than that of the control group (t =10.51, P =0.00), short time recovery success rate, total recovery rate were higher than that of control group (χ2=14.38,χ2=13.25, P <0.01).After 1 h of recovery, the observation group of peripheral blood myocardial enzyme spectrum index of cardiac troponin I (cTn I), lactate dehydrogenase (LDH), creatine kinase (CK) levels lower than the control group (t =7.82, t =9.27, t =12.34, P <0.05), serum nerve injury index of neuron specific enolase (NSE), S100B protein (S100B) were lower than control group, brain-derived neurotrophic factor (BDNF) was higher than that of the control group (t =12.38, t =6.82, t =9.27, P <0.05, P <0.01).Conclusion Mechanical chest compressions can optimize the rescue effect of cardiac arrest patients, reduce myocardial injury during compression and improve neurological function.