The level of serum sex hormone binding globulin in patients with type 2 diabetes mellitus complicated with metabolic syndrome influence research
GUO Yifei
LI Xuefeng
ZENG Yuqing
CAI Junwei
LI Min
Abstract：Objective To investigate the effect of serum sex hormone binding globulin (SHBG) on type 2 diabetes mellitus with metabolic syndrome.Methods Two hundred and twenty cases of type 2 diabetes mellitus treated in endocrine and rheumatoid department were selected as the research object.According to the diagnostic criteria of metabolic syndrome, the patients were divided into two groups.The patients were divided into five groups, group A (type 2 diabetes mellitus group), group B (type 2 diabetes mellitus with one diagnostic syndrome group), group C (type 2 diabetes mellitus with 2 metabolic syndrome diagnostic criteria group), group D (type 2 diabetes mellitus combined with 3 diagnostic criteria for metabolic syndrome), group E (type 2 diabetes with 4 metabolic syndrome diagnostic criteria group), 44 patients in each group.Comparative analysis of the five groups of indicators and their relationship with the SHBG were performed.Results There were significant differences in BMI,systolic blood pressure, diastolic blood pressure, waist circumference,triglyceride, high density lipoprotein cholesterol, serum uric acid,fasting insulin,insulin resistance index,male/female serum sex hormone binding globulin.Pearson correlation analysis showed that serum sex hormone levels were correlated with BMI, waist circumference, fasting blood glucose, triglyceride,uric acid,fasting insulin,insulin resistance index(r =-0.33, r =-0.32, r =-0.47, r =-0.43, r =-0.49, r =-0.44, r =-0.49, P <0.05), and there was a linear positive correlation with HDL-C (r =0.34, P <0.05).Conclusion The serum levels of sex hormone binding globulin level in type 2 diabetes with metabolic syndrome patients have certain effect.Therefore, the treatment should be with early detection and symptomatic treatment to prevent further deterioration of the disease.
Keywords：Diabetes mellitustype 2Metabolic syndromeSerum sex hormone binding globulinEffect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 911-914 )