Effect of dual plasma molecular adsorbent system on serum inflammatory factors, liver function and immune function in patients with chronic liver failure
TANG Juan
DENG Wei
TANG Jing
ZHOU Limin
Abstract：Objective To observe the effect of double plasma molecular adsorbent system on serum anti inflammatory factors and proinflammatory factors in patients with chronic liver failure.Methods From August 2015 to October 2016, 80 cases with acute or chronic liver failure in Zigong First People's Hospital of Sichuan province enrolled as the research object, they were randomly divided into control group and observation group, 40 cases in each group, the control group using plasma exchange treatment, observation group used double plasma molecular adsorption systematic treatment, adverse reaction, clinical observation, 2 groups of serum inflammation factor, liver function, immune function were compared.Results After treatment, the effective rate of the observation group was 87.50%, which higher than that of the control group's 67.50% (χ2=4.587, P =0.032).Observation group's IL-10, IL-17, TGF-β, CD4+, CD4+/CD8+ higher than that of the control group[(131.40±13.62)ng/L vs.(119.70±12.57)ng/L,(261.40±23.21)ng/L vs.(251.26±20.85)ng/L,(180.43±23.58)mg/L vs.(162.27±21.48)mg/L,(35.43±4.85)% vs.(32.31±4.20)%,(1.24±0.28) vs.(1.09±0.21), t=3.992, t =2.055, t =3.600, t =3.174, t =2.710, P =0.000, P =0.043, P =0.000, P =0.002, P =0.008],observation group's CRP, IL-6, TNF-α, ALT, DBil, TBil, CD8+ lower than that of the control group[(16.30±3.27)mg/L vs.(19.61±4.10)mg/L,(8.60±1.13)ng/L vs.(16.50±2.25)ng/L,(142.61±21.08)mg/L vs.(158.30±23.60)mg/L,(151.49±15.43)IU/L vs.(170.78±16.32)IU/L,(149.30±16.50)μmol/L vs.(169.23±17.14)μmol/L,(228.54±18.11)mol/L vs.(240.51±19.67)mol/L,(28.26±4.50)% vs.(31.19±4.87)% , t =3.991, t =19.844, t =3.135, t =5.432, t =5.298, t =2.831, t =2.794, P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0.000, P =0.006].There was no significant difference in adverse reactions between the 2 groups (P >0.05).Conclusion Dual plasma adsorption system can effectively eliminate the proinflammatory factors in patients with chronic liver failure, promote the expression of anti-inflammatory factors, and restore the dynamic balance between the two groups.
Keywords：Acute and chronic liver failureDouble plasma molecular adsorption systemAnti-inflammatory factorProinflammatory factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 903-906,910 )