The effects of clinical curative effect, inflammatory factors and immune function of continuous venous-venous hemodialysis treatment of patients with acute renal failure
CUI Xuebin
ZOU Ting
TANG Xiaotie
YU Yang
Abstract：Objective To observe the effect of continuous veno-venous hemodiafiltration on severe acute renal failure and its influence on inflammatory factors and immune function.Methods From April 2015 to March 2016, 68 cases of severe acute renal failure in Puren Hospital were enrolled as the research object, they were randomly divided into 2 groups with 34 cases in each group, the control group used traditional intermittent hemodialysis therapy, the observation group with continuous veno-venous hemofiltration treatment, compared the clinical efficacy of 2 groups, serum inflammatory factor, immune function, renal function, adverse reactions and other indicators were measured and compared.Results The total effective rate of the observation group was significantly higher than that of the control group (97.06% vs.82.35%,χ2=3.981, P =0.032).Compared with before treatment, the 2 groups after treatment of serum interleukin 6 (IL-6), IL-8, tumor necrosis factor alpha (TNF-α) content decreased significantly, and the observation group more obviously than the control group (t =7.813, t =8.710, t =5.623, P =0.006, P=0.002, P =0.011);immune function of 2 groups after treatment were improved.And the observation group CD3+, CD4+ and CD4+/CD8+ were significantly higher than the control group, CD8+ was significantly lower than the control group (t =5.525, t =3.623, t =2.714, t =2.346, P =0.013, P =0.028, P =0.026, P =0.033);compared with before treatment, the 2 groups after treatment serum creatinine (SCr), urea nitrogen (BUN) content decreased obviously, and the observation group than the control group (t =10.697, t =6.684, P <0.01).There was no significant difference in adverse reactions between the 2 groups (20.59% vs.17.65%,χ2=0.095, P =0.906).Conclusion Continuous veno-venous hemofiltration treatment helps restore severe acute renal failure in patients with renal function, improve clinical efficacy, and may reduce the serum inflammatory factor in regulating immune function.
Keywords：Renal failureacuteContinuous venous-venous hemodialysisInflammatory factorsImmune function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 899-902 )