Occurrence of intracranial atherosclerosis in elderly patients with diabetes and subclinical hypothyroidism and its influencing factors

SUI Miao; YU Yang; ZHANG Tao; XU Jingyi; YANG Xiaohui

doi:10.3969/j.issn.1671-6450.2017.09.004

Abstract：Objective To investigate the occurrence of intracranial atherosclerosis in elderly patients with subclinical hypothyroidism and diabetes and its influencing factors.Methods Eighty-four cases (38 males and 46 females) of patients with diabetes were selected, who were treated in hospital from February 2015 to February 2016, and they were divided into the diabetes+subclinical hypothyroidism (DM + SCH) group (44 cases) and diabetes(DM) group (40 cases) which based on thyroid function results.The clinic basic data, intracranial atherosclerosis and biochemical markers of the two groups were analyzed, and the intracranial atherosclerosis was used as the dependent variable, the patients' basic data and clinical biochemical parameters were taken as independent variables, which were added to the logistic regression equation, to analyze the influencing factors of intracranial atherosclerosis in patients with subclinical hypothyroidism and diabetes.Results The systolic blood pressure, TPOAb,TSH,HDL-C, SCr,FIB,hs-CRP, Hcy, intracranial atherosclerosis of the DM+SCH group were significantly higher than those of the DM group ( t =3.476, t =2.467, t =13.690, t =1.957, t =4.103, t =2.018, t =5.919, t =8.394, P =0.000, P =0.008, P =0.027, P =0.000, P =0.000, P =0.023, P =0.000, P =0.000);Multivariate logistic regression analysis showed that systolic blood pressure,SCr,hs-CRP, Hcy, FIB, TSH were risk factors of intracranial atherosclerosis,HDL-C was protective factor.Conclusion Subclinical hypothyroidism in patients with diabetes increases the risk of intracranial atherosclerosis, and the blood lipid, inflammatory reaction, coagulation and fibrinolysis system, homocysteine and thyroid stimulating hormone are the influencing factors of intracranial atherosclerosis.