Effects of urinary kallidinogenase and butyphthalide on cognitive function and serum inflammatory cytokines in patients with ACI
WANG Weihong
MENG Lanfang
JI Yuhong
TENG Haiying
Abstract：Objective To investigate the effects of urinary kallidinogenase and butyphthalide on cognitive function and serum inflammatory cytokines in patients with acute cerebral infarction (ACI).Methods One hundred and thirty-six ACI patients (based on cranial CT and MRI diagnosis) admitted to hospital (from January 2014 to December 2015) were retrospectively analyzed, 70 patients were treated with conventional treatment based on the use of urinary kallidinogenase combined with butyphthalide (study group), 66 patients were only received conventional treatment (control group), the patients of two groups were treated for 4 weeks.The neurologic impairment scale (NIHSS) was used to evaluate the central nervous system function, cognitive function of patients was evaluated by Mini Mental State Scale (MMSE) score, and biological enzyme linked immunosorbent assay (ELISA) was used to detect serum factors related index.The NIHSS score, MMSE score and serum factors related index of two groups patients were compared before treatment, treatment for 2 weeks and 4 weeks.Results Before treatment, there was no significant difference in NIHSS and MMSE score between the two groups( t =1.191,1.145, P >0.05).After treatment for 2 weeks and 4 weeks, the NIHSS scores of the study group were lower than those of the control group( t =4.017, t =5.676, P =0.000, P =0.000);After treatment for 4 weeks, the MMSE scores of the study group were higher than those of the control group( t =2.515, P =0.013);Before treatment, the serum levels of sCD40L, IL-18, hs-CRP, NO, eNOS and VEGF of the two groups were not statistically significant( t =1.398, t =0.885, t =0.429, t =0.395, t =0.619, t =0.822, P =0.165, P =0.384, P =0.573, P =0.628, P =0.498, P =0.408).After treatment for 2 weeks and 4 weeks, the serum levels of sCD40L, IL-18 and hs-CRP of the study group were lower than those of the control group( t =6.055, t =6.898, t =5.574, t =4.023, t =4.104, t =6.751, P =0.000, P =0.000, P =0.000, P=0.000, P =0.000, P =0.000),and the levels of NO, eNOS and VEGF of the study group were higher than those of the control group( t =2.814, t =3.904, t =3.028, t =5.574, t =3.518, t =2.708, P =0.010, P =0.000, P =0.002, P=0.000, P =0.000, P =0.012).Conclusion The urinary kallidinogenase and butyphthalide in the treatment of patients with ACI can promote cognitive function, neurological function recovery, reduce inflammatory response.
Keywords：Urinary kallidinogenaseButyphthalideCerebral infarctionacuteCognitive functionInflammatory response
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 873-876 )