The relationship between 25 hydroxyvitamin D level and chronic hepatitis C: a Meta-analysis
JIAO Fangzhou
ZHANG Haiyue
ZHANG Wenbin
GONG Zuojiong
Abstract：Objective To review the relationships between 25 hydroxyvitamin D3[25(OH)D3]levels and chronic hepatitis C.Methods We searched Cochrane Library,Medline,PubMed,Chinese Biomedical Literature Database(CBM),VIP,CNKI,and Wanfang database of English and Chinese studies reporting the relationship between 25 hydroxyvitamin D levels and chronic hepatitis D form establish of the database to March 1,2017.Results Twelve studies(n=1 144)were finally included,737 cases in CHC group and 407 in control group.The results of meta-analysis showed that 25(OH)D3 in patients with CHC was lower than the control group individuals(SMD=-1.59,95％CI-2.37～-0.80,P<0.01).The subgroup analysis of ethnicity,the CHC group was lower than the control group in the serum 25(OH)D3 levels for both Asian and Egyptian(SMD=-2.48,95％CI-3.58～-1.38,P<0.01;SMD=-2.10,95％CI-3.23～-0.96,P<0.01),while there was no statistical difference for White(SMD=-0.20,95％CI-1.42～-1.03,P=0.75).In the subgroup analysis of detection method for 25(OH)D3,both of ELISA and chromatography showed that the serum 25(OH)D3 levels in CHC group was lower than the control group(SMD=-2.39,95％CI-3.22～-1.56,P<0.01;SMD=-1.75,95％CI-2.06～-1.44,P<0.01).The result of the study showed no bias and reliable according to publication bias analysis and sensitivity analysis.Conclusion The 25 hydroxyvitamin D level was lower in chronic hepatitis C patients than health control.Due to the small of sample sizes,more high quality,large sample studies are needed to verify the results.
Keywords：Chronic hepatitis C25 hydroxy vitamin DMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 825-829 )