Effects of combination salvia miltiorrhiza and ligustrazine on the levels of hs-CRP, cTnT and NT-proBNP in patients with chronic kidney disease
ZHANG Yukun
QIU Yuhua
WANG Yiping
LI Muzi
ZHANG Xuefeng
Abstract：Objective To observe the effects of salvia miltiorrhiza and ligustrazine on the expression of hs-CRP,cTnT and NT-proBNP in patients with chronic kidney disease.Methods One hundred patients of chronic kidney disease who received therapy from April 2014 to April 2016 were selected as research objects,according to random number table method,these patients were divided into the observation group(n=50)and the control group(n=50).The control group was treated with routine treatment,while the observation group on the basis of conventional treatment used Danshen ligustrazine combined with alprostadil for treatment.Then total cholesterol,triacylglycerol,high density lipoprotein,low density lipoprotein,urea nitrogen,serum creatinine,urinary albumin,highly sensitive C reactive protein,cardiac troponin T,NT-proBNP were compared between groups.Results After treatment,the clinical efficacy of the observation group was significantly better than the control group(74.0％vs.40.0％,x2=11.791,P=0.001).TC levels were lower in the observation group than in the control group[(5.41±0.43)mmol/L vs.(5.98±0.49)mmol/L,t=6.183,P=0.000].TG levels were lower in the observation group than in the control group[(1.32±0.18)mmol/L vs.(2.22±0.28)mmol/L,t=19.119,P=0.000).LDL level was lower in the observation group than in the control group[(3.01±0.31)mmol/L vs.(3.39±0.61)mmol/L,t=3.927,P=0.000].HDL-C level of the 2 group were increased,but the difference between the two groups was not obvious[(1.41±0.09)mmol/L vs.(1.51±0.49)mmol/L,t=1.419,P=0.159].BUN in observation group was lower than the control group[(12.51±2.14)μmol/L vs.(16.15±2.18)μmol/L,t=8.426,P=0.000].Scr in observation group was lower than the control group[(219.52±98.63)mmol/L vs.(272.12±101.41)mmol/L,t=2.629,P=0.010].Upro in observation group was lower than the control group[(1.31±0.54)g/24h vs.(1.89±0.38)g/24h,t=6.211,P=0.000].hs-CRP levels were lower in the control group than in the control group[(4.94±1.28)mg/L vs.(5.82±2.59)mg/L,t=2.111,P=0.037].CTnT levels were lower than those in the control group [(13.46±1.73)μg/ml vs.(18.96±1.97)μg/ml,t=14.834,P=0.000].NT-proBNP levels were lower than those in the control group[(5 147.14±26.79)pg/ml vs.(6 128.74±31.31)pg/ml,t=168.441,P=0.000].The overall incidence of adverse reactions in the observation group was significantly lower than that in the control group(12.0％vs.28.0％,x2=4.000,P=0.046).Conclusion Danshen ligustrazine combined with alprostadil in the treatment of chronic kidney disease can effectively reduce the level of hs-CRP,cTnT and NT-proBNP,enhance the clinical efficacy,and reduce the incidence of adverse reactions after treatment,it is worthy promoting the use of it.
Keywords：Salvia miltiorrhizaAlgaeKidney diseasechronicBiochemical indicators
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 796-800 )