Clinical study of the change of serum 25-hydroxy vitamin D level in early type 2 diabetic patients and its correlation
BAO Chunchun
LI Dongmei
SIQIN Gaowa
JIA Haiqin
AO Rihan
Abstract：Objective To analyze the change and related factors of serum 25-hydroxyvitamin D(25(OH)D)level in early type 2 diabetic patients.Methods 143 early type 2 diabetic patients in department of Endocrinology of the People''s Hospital of Inner Mongolia Autonomous Region from May 2014 to August 2016 were selected as observation group,and 140 healthy people were randomly selected in our hospital during the same period as control group.According to the level of 25(OH)D,all the patients in the observation group were divided into group A(n=97)and group B(n=46).It compared the differences of BMI,FPG,Fins,HOMA-IR,25(OH)D,TC,TG,OH,HDL-C,LDL-C,SBP,DBP,mAlb,hs-CRP,and analyzed the correlation with other variables between the two groups.Results The level of BMI,FPG,HOMA-IR,TG,SBP,DBP,hs-CRP and mAlb in the observation group were significantly higher than those of in the control group(t=2.608,t=13.757,t=3.826,t=2.895,t=9.523,t=10.622,t=26.263,t=36.167,P<0.05,P<0.01),and Fins,25(OH)D and HDL-C were lower than those of in the control group(t=-19.366,t=-7.952,t=-13.014,P<0.05,P<0.01).The level of BMI,FPG,TG,hs-CRP and mAlb in the group A were significantly higher than those of in the group B(t=2.185,t=3.069,t=2.895,t=9.837,t=7.928,P<0.05,P<0.01),and Fins,HOMA-IR and HDL-C were lower than those of in the group B(t=-6.161,t=-5.060,t=-8.997,P<0.05,P<0.01).The serum level of 25(OH)D is negatively correlated with BMI,HOMA-IR,D level and TG,hs-CRP and mAlb were negatively correlated(r=-0.293,r=-0.289,r=-0.398,r=-0.311,r=-0.505,P<0.05,P<0.01),and is positively correlated with Fins and HDL-C(r=0.306,r=0.291,P<0.05,P<0.01).There is no significant correlation when it correlated with FPG,TC,LDL-C,SBP and DBP(P>0.05).The factors associated with pre diabetes were BMI,Fins,HOMA-IR,TG,HDL-C,and mAlb(P<0.05).Conclusion The serum level of 25(OH)D in early type 2 diabetic patients is lower than that of in healthy control group.The serum level of 25(OH)D is negatively correlated with BMI,HOMA-IR,TG,hs-CRP and mAlb,meanwhile,and is positively correlated with Fins and HDL-C.There is no significant correlation when it correlated with FPG,TC,LDL-C,SBP and DBP.
Keywords：Early type 2 diabetes25-hydroxy vitamin DInsulin resistanceBlood glucoseCorrelation analysis
Publication Date：2017-01-01
Pages：5( 792-795,800 )