Relationship between serum PARK7, LPA and D-dimer and carotid atherosclerosis and degree of neurological deficit in stroke patients

HUANG Hongliang; YANG Lili; HUANG Wei; HUANG Fayu; CHEN Rui

doi:10.3969/j.issn.1671-6450.2017.08.006

Abstract：Objective To investigate the relationship between serum levels of PARK7,LPA and D-dimer(D-D)in patients with stroke and the degree of carotid atherosclerosis and nerve defect.Methods One hundred and twenty cases of patients with acute stroke from Jingmen second people''s hospital were divided into non-plaque group(n=20),plaque stable group(n=48)and unstable plaque group(n=52)accorded to carotid intima media thickness(IMT)from October 2015 to October 2016.40 cases of healthy volunteers were selected as the control group.The levels of PARK7,LPA and D-D in the serum of each group were measured by ELISA.The neurological deficits of patients with acute stroke were assessed with NIHSS scoring scale.Results The levels of PARK7,LPA and D-D of unstable plaque group were higher than stable plaque group and non-plaque group,the levels of PARK7,LPA and D-D in stable plaque group were higher than non-Plaque group(F=127.53,F=325.37,F=242.49,P<0.01).The levels of PARK7,LPA and D-D in the moderate and severe nerve defect groups were significantly higher than mild neurologic deficits group,while the levels of PARK7,LPA and D-D in severe nerve defect group were higher than moderate group(F=166.99,F=177.44,F=228.12,P<0.05).The levels of PARK7,LPA and D-D of progressive stroke were higher than stroke patients(t=7.991,t=5.626,t=19.887,P<0.01).The levels of serum PARK7,LPA and D D in dead group were higher than survival group(t=11.162,t=4.209,t=28.825,P<0.01).The levels of PARK7,LPA and D-D were positive correlated with IMT and NIHSS by Pearson univariate analysis(RIMT=0.352、0.315、0.329;RNIHSS=0.345、0.329、0.338,P<0.01).Conclusion The levels of serum PARK7,LPA and D-D in patients with acute stroke are closely related to the stability of carotid plaque and the degree of neurological deficit.It can be used as an important index to evaluate the prognosis of stroke patients.