Effect of Jinlida granule on serum nesfatin-1 level and islet β cell function in patients with pre-diabetes
CAI Jing
ZHAO Zhigang
ZHANG Lishuang
ZHANG Mengyao
DONG Lina
QIN Yingjun
Abstract：Objective To observe the effect of Jinlida granule on serum nesfatin-1 level and islet β cell function in treating patients with pre-diabetes.Methods Sixty of pre-diabetes patients were randomly divided into 2 groups, 30 case in control group and 30 case in the observation group.Control group received diet and exercise therapy;the observation group therapy based on diet and exercise plus Jinlida granule treatment for 12 weeks.Before and 12 weeks after treatment, compared of the two groups nesfatin 1 and indicators of change.Results After treatment, the total effective rate of observation group was higher than the control group (80.0% vs.46.7%,X2=7.177,P=0.007).The observation group patients serum nesfatin-1, 2 h PG, HbA1c, FINs, HOMA-IR and BMI levels were lower than the control group (t=2.002,P=0.048;t=2.771,P=0.007;t=3.216,P=0.002;t=2.198,P=0.030;t=2.279,P=0.048;t=2.675,P=0.009);while the FPG, SBP, DBP, TC, TG, HDL-C and LDL-C levels of patients after treatment in the 2 groups had no significant change(t=1.432,P=0.155;t=0.221,P=0.825;t=0.086,P=0.933;t=0.593,P=0.554;t=0.881,P=0.380;t=1.168,P=0.246;t=1.556,P=0.122).Conclusion It demonstrated that the Jinlida granule could correct the disorder of glucose metabolism in patients with pre-diabetes, decrease the level of serum nesfatin-1, and effectively improve the function of islet beta cells.
Keywords：Pre-diabetic stateJinlida granuleNesfatin-1Pancreatic β cell
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 720-723 )