Effect of noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower on severe cor pulmonale combination of respiratory failure
YAN Si
FU Zhiyue
LI Cui
YAN Guanghuan
MENG Xujun
Abstract：Objective To observe effect of noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower on severe cor pulmonale combination of respiratory failure.Methods From October 2014 to September 2015, selecting 65 cases of severe cor pulmonale combination of respiratory failure patients in the hospital, according to the random number method, patients were divided into observation group (33 cases) and control group (32 cases).Control group were taken regular medicine comprehensive treatment with noninvasive positive pressure ventilation therapy, observation group were treated with naloxone with saffower yellower for treatment on the basis of control group.Before and after treatment, patients with arterial blood oxygen partial pressure, arterial blood (PaO2), partial pressure CO2 (PaCO2), blood pH value (pH), heart rate and breathing rate were tested.The clinical efficacy and adverse reactions were observed.Results After treatment, the total clinical efficacy rate in the observation was significantly higher than the control group [93.94% (31/33) vs.71.88%(23/32),X2=23.633,P<0.01].PaO2 of observation group was significantly higher than control group [(68.32±6.84) mmHg vs.(56.32±5.11) mmHg], PaCO2 was significantly lower than the control group[(46.43±4.11) mmHg vs.(69.43±5.43) mmHg],the difference had statistical significance (t=7.994,t=19.293,P<0.01).After treatment, the observation group's heart rate, respiratory frequency were significantly lower than the control group[(101.11±4.32) times/min vs.(106.43±6.73) times/min;(21.43±0.25) times/min vs.(25.65±0.34) times/min,t=3.804,t=57.135,P<0.01].Observation group and control group rate of adverse reactions had no significant difference(P>0.05). Conclusion Severe cor pulmonale combination of respiratory failure treated with noninvasive positive pressure ventilation auxiliary joint naloxone with saffower yellower can reduce PaCO2,improve PaO2,can reduce the heart rate and breathing rate,it is conducive to the improvement of clinical symptoms, clinical curative effect is good with high safety.
Keywords：Noninvasive positive pressure ventilationNaloxoneSaffower yellowerCor pulmonaleRespiratory failure
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 678-681 )