The relationship between vitamin D deficiency and aortic dissection
HUANG Jizhen
WANG Zhiwei
HU Zhipeng
LI Bowen
Abstract：Objective To detect the serum 25 hydroxy vitamin D in aortic dissection patients, and to investigate the relationship between vitamin D deficiency and aortic dissection.Methods Sixty two aortic dissection patients and seventy one healthy donors were included in Renmin Hospital of Wuhan University from Nov 2015 to Nov 2016.Serum 25 hydroxyvitamin D levels were measured by enzyme linked immunosorbent assay (ELISA).Logistic stepwise regression model was established to screen the risk factors of aortic dissection.Results The serum 25 hydroxy-vitamin D level in aortic dissection patients was (16.56±7.51) ng/ml,and the level in healthy donors was (25.21±8.57) ng/ml;the difference was statistically significant (t=6.143,P=0.000).The proportion of vitamin D deficiency in aortic dissection group was 74.2%, the proportion of vitamin D deficiency in the control group was 28.2%, and the proportion of vitamin D deficiency in aortic dissection group was about 2.6 times higher than that in the control group(X2=28.095,P<0.01).Logistic stepwise regression analysis showed that vitamin D(OR=0.271,P=0.000), blood HDL-C(OR=0.446,P=0.023)and hypertension history(OR=3.066,P=0.011)were independent predictors of aortic dissection.Conclusion It suggested that the vitamin D deficiency was prevalent in AD patients and was an independent risk factor linked to aortic dissection.
Keywords：Aortic dissectionVitamin D deficiency25 hydroxy vitamin DCorrelation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 649-652 )