Changes of serum TNF-α, free fatty acids and adiponectin levels in patients with different glucose tolerance
CHEN Kaiting
HAO Yanan
DONG Xueqin
GAO Ying
TAN Mi
LIU Yiran
ZHANG Xiaoqing
LI Hongyan
AN Yanrong
Abstract：Objective To analyze the changes of tumor necrosis factor alpha (TNF-α), free fatty acid (FFA) and adiponectin (APN) and its influencing factors in patients with different glucose tolerance.Methods From March 2014 to March 2015, select the first hospital of Shijiazhuang City Department of endocrine treatment of type 2 diabetes mellitus (DM group), impaired glucose tolerance (group IGT), patients with the same period in healthy physical examination in our hospital patients (NGT group), 30 cases in each group respectively as the research object, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triacylglycerol (TG), total cholesterol (TC) and insulin resistance index (HOMA-IR), TNF-α, FFA and APN alpha detection index, and risk factor analysis.Result Comparison of serum TNF-α, FFA levels: NGT group <IGT group <DM (F=2.711,P=0.014;F=3.274,P=0.008), serum APN level comparison: group >IGT group >DM group (F=3.014,P=0.011).TNF-α , FFA and TG, FPG, FINS, HOMA-IR, HbA1c in the DM group was significantly positive correlation (r=0.410,r=0.274,r=0.428,r=0.490,r=0.400,P=0.000;r=0.420,r=0.350,r=0.370,r=0.480,r=0.410,P=0.000), APN was negatively correlated with TG, FPG, FINS HOMA-IR, HbA1c (r=-0.410,r=-0.370,r=-0.370,r=-0.490,r=-0.400,P=0.000).Hypertriglyceridemia, hypercholesterolemia, hypertension, HOMA-IR, TNF-α, FFA, APN were risk factor of diabetes mellitus [OR (95%CI)=1.739 (1.286-2.353), OR (95%CI)=1.486 (1.096-2.016),OR(95%CI)=1.743 (1.290-2.356),OR (95%CI) =2.302 (1.707-3.104), OR (95%CI) =1.624 (1.135-2.321), OR (95%CI) =1.212 (1.081-1.359),OR (95%CI) =0.665 (0.500-0.884)].Conclusion TNF-α, FFA and APN may play an important role in the occurrence and development of diabetes, so it is necessary to strengthen the early intervention of lipid metabolism and related fat factors.
Keywords：Diabetes mellitustype 2Tumor necrosis factor αFree fatty acidAdiponectin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 592-595 )