Clinical analysis of the relationship between mean platelet volume and colon cancer

WANG Yongqiang; WU Xiaowei; WANG Ji; PENG Huajun; ZHOU Zhongyin

doi:10.3969/j.issn.1671-6450.2017.06.012

Abstract：Objective To evaluate the clinical value of elevated MPV in patients with colon carcinoma.Methods A total of 146 colon carcinoma patients as well as 154 age and sex matched healthy cases were selected during September 2014 to September 2016 from Hanyang Hospital and Renmin Hospital of Wuhan University.MPV was compared among the two groups pre and after surgery.MPV levels were calculated, and MPV was analyzed according to different clinic pathological features in colon carcinoma patients.Besides, a ROC curve was applied to analyze the best cut off value of MPV for diagnosing carcinoma of colon.Results The MPV(t=9.446,P<0.01) and PLT(t=2.792,P=0.006)were higher and the Hb(t=2.990,P=0.003)was lower in colon cancer group than those in the controls.The patients who had experienced distant metastasis(t=2.009,P=0.046)and those who were in stage III to IV(t=2.438,P=0.014)had a high level of MPV.Correlation analysis revealed that MPV was positively correlated with organ metastasis and III to IV stage tumor (r=0.561,r=0.599,P=0.042,P=0.016, respectively), but there was no correlation between MPV and depth of infiltration, degree of differentiation and lymph node metastasis (r=0.060,r=-0.116,r=0.115,P>0.05).Both MPV (t=3.987,P<0.01) and PLT (t=1.696,P=0.033)were decreased after surgery compared to that in pre-operative.ROC analysis suggested that the best cutoff value of MPV was 11.95 fl to diagnose cancer of colon (AUC=0.779,95%CI0.727-0.832,sensitivity 82.2%, specificity 61.1%).Conclusion The increase of MPV level in patients with colon cancer has important clinical significance.MPV may be an important marker for the diagnosis and prognosis of colon cancer.