Effect of salbutamol sulfate and budesonide micro-pump inhalation on infantile asthma and its effects on serum levels of IL-1β and IL-12

XU Muzhen; CHEN Feng; PAN Rui; NIE Yujun

doi:10.3969/j.issn.1671-6450.2017.05.016

Abstract：Objective To investigate the efficacy of salbutamol sulfate and budesonide micro-pump inhalation on infantile asthma and its effects on serum levels of IL-1β and IL-12.Methods 132 infants with asthma were enrolled in the Department of Pediatrics of Xiangyang Central Hospital Affiliated to Hubei University of Arts and Sciences from January 2014 to January 2016,were randomly assigned into two groups according to their order of admission,each 66 example. The control group was treated with routine asthma (anti-infection, cough and phlegm, aminophylline, dexamethasone, etc.), the study group of children in the control group based on the treatment of children with salbutamol sulfate solution + budesonide suspension Micro-pump inhalation therapy, compared the two groups of children with the clinical curative effect, the disappearance time of symptoms and the levels of serum IL-1β and IL-12 before and after treatment.Results The total effective rate in the study group was 100.0%,the total effective rate in the control group was 89.4%, the total effective rate in the study group was better than that in the control group (χ2=6.235,P<0.05).The serum levels of IL-1β and IL-12 in the two groups were significantly lower than those before treatment (P<0.05), and the serum IL-1β and IL-12 in study group were significantly lower than control group(t=4.865,t=5.894,P<0.05).Conclusion The use of budesonide and salbutamol sulfate solution inhalation of micro-pump in children with infant asthma, can improve the clinical treatment of children, help to relieve symptoms in children, improve the patient's symptoms, and can reduce the serum IL-1β and IL-12 level, worthy of clinical application.