The diagnostic value and long term prognosis of serum CD44, NGAL, MIC-1 in the colorectal cancer
CHEN Weirong
LI Ping
LI Shefang
HU Junjun
MING Tao
Abstract：Objective To investigate the phagocyte glycoprotein 1 (CD44), neutrophil gelatinase associated lipocalin (NGAL), macrophage inhibitory factor 1 (MIC-1) application in diagnosis and long-term prognosis in colorectal cancer.Methods Sixty cases of histological confirmed colorectal cancer patients were selected as study group, and collected 60 normal tissues (from the tumor > 5 cm) enrolled as the control group from January 2012 to December 2015. The expression levels of CD44, NGAL, MIC-1 were measured with immunohistochemical method and the relationships of CD44, NGAL, MIC-1 with the clinicopathological data and prognosis were analyzed.Results The study group CD44, NGAL, MIC-1 positive expression rates were 86.67%, 80.00%, 70.00%, significantly higher than that of control group 16.67%, 20.00%, 13.33%, the differences were statistically significant (χ2=58.865,43.200,39.634,P<0.05). The expression of CD44 and age, the degree of infiltration, degree of differentiation, lymph node metastasis (χ2=7.552,χ2=9.650,χ2=6.593,χ2=6.154,P<0.05), the expression of NGAL and the depth of tumor invasion, tumor stage, lymph node metastasis (χ2/U=10.714,χ2/U=15.000,χ2/U=10.000,P<0.05), MIC-1 and the degree of tumor differentiation, tumor stage, invasion depth and lymph node metastasis (χ2/U=12.862,χ2/U=6.612,χ2/U=15.556,χ2/U=17.143,P<0.05). The positive expression of CD44 in the 3 year survival rate was 53.33%(32/60),lower than the negative expression of CD44's 100.00% (8/8) (χ2=6.347,P=0.012); the positive expression of NGAL in the 3 year survival rate was 60.42% (29/48), lower than the negative expression of NGAL's 91.67% (11/12) (χ2=4.219,P=0.040); the positive expression of MIC-1's 3 year survival rate was 57.14% (24/42),lower than that of MIC negative expression in 88.89% (16/18) (χ2=5.714,P=0.017).Conclusion The expression of CD44,NGAL,MIC-1 has a close relationship with the occurrence,progression and survival rate of colorectal cancer,and the combined detection of the expression of the three cases will contribute to the clinical diagnosis and prognosis of colorectal cancer.
Keywords：Phagocyte glycoprotein 1Neutrophil gelatinase associated lipocalinMacrophage inhibitory factor 1Colorectal cancerPrognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 485-488 )