Efficacy of combined mechanical thrombectomy with Solitaire stent and intra-venous thrombolysis in patients with acute intracranial large artery occlusion
WANG Yu
LI Xiaoqiang
KONG Yongmei
LI Guofeng
WEI Yuqing
Abstract：Objective To investigate the efficacy and safety of mechanical thrombectomy with Solitaire stent and intra-venous thrombolysis in patients with acute intracranial artery occlusion.Methods The 19 patients with acute stroke (in 4.5h intravenous thrombolysis time window) who were carried out intra-venous thrombolysis and mechanical thrombectomy with Solitaire stent were enrolled from Jan 2015 to Aug 2016. There were 11cases of middle cerebral artery occlusion, 4 cases of internal artery occlusion, 4 cases of basilar artery occlusion. To observe the clinical efficacy and safety of intravenous rt-PA thrombolysis combined with mechanical thrombectomy with Solitaire stent in the treatment of acute intracranial arterial occlusion.Results Occluded large arteries of 19 patients were dredged totally or partially, the recanalization rate or partial recanalization rate of blocked blood vessel was 89.5%, including 15 cases with total recanalization (79.0%), 2 cases with partial recanalization (10.5%). There are two patients cannot be re-canalized. After operation, two cases suffered from cerebral hemorrhage,two patients died. The target blood flow can reached form two to three grade. The ranks of NIHSS and ADL between pre-operation and after operation were discrepant obviously(F=18.85,35.83,P=0.00). The degree of disability score showed no significant difference between leaving and 3 months after departure from the hospital(U=1.60,P>0.05).Conclusion Mechanical thrombectomy with Solitaire stent and intra-venous thrombolysis in patients with acute intracranial large artery occlusion is a safe and an effective therapy with in 4.5h intravenous thrombolysis time window.
Keywords：Brain ischemiaIntracranial large artery occlusionIntra-venous thrombolysisSolitaire stentMechanical thrombectomy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 461-464 )