Effect of Xiezhuojiedu decoction on TLR4,MD2,IL-13,NF-κB on ulcerative colitis model rats
LIU Jianping
YANG Qianyu
LANG Xiaomeng
ZHAO Yuan
YAO Cuicui
Abstract：Objective To observe the effects of Xiezhuojiedu decoction on TLR4, MD2, IL-13 and NF-κB of ulcera-tive colitis( UC) rats .Methods Established the animal models of ulcerative colitis with TNBS /ethanol joint modeling meth-od.After the irrigation treatment, the expression of TLR4, the content of MD2, IL-13 and NF-κB in serum were detected, re-spectively.Results Xiezhuojiedu decoction can decrease the expression of TLR 4, MD2 and NF-κB,improve the level of IL-13.The comparison between the two groups showed statistical significance ( F =110.490, F =271.137, F =10.723, F =92.297, P <0.05).Conclusion The effects of Xiezhuojiedu decoction on UC rats are remarkable ,it may be related to de-creasing the expression of TLR4,MD2, and NF-κB,improving the level of IL-13.
Keywords：Ulcerative colitisXiezhuojiedu decoctionTLR4MD2IL-13NF-κB
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 381-384 )