Effect of FAC regimen chemotherapy on oxidative stress in patients with advanced breast cancer
HUANG Jinghui
YOU Dongshan
CHEN Xin
ZHOU Yunna
CHEN Aiming
Abstract：Objective To observe the effect of FAC ( 5 fluorouracil , cyclophosphamide , adriamycin ) chemotherapy on the level of oxidative stress in patients with advanced breast cancer .Methods From May 2014 to May 2015 , 68 patients with advanced breast cancer were treated in the Department of oncology , the first people 's Hospital of Chuzhou city .The pa-tients were randomly divided into observation group and control group ( n =34 ) .The control group was treated with TAC chemotherapy , the observation group was treated with FAC chemotherapy;2 groups of patients with continuous chemotherapy of 21 d for 1 cycles, compared the clinical efficacy of the 2 groups after 3 weeks of chemotherapy and nitric oxide (NO), ma-londialdehyde (MDA), glutathione peroxidase (GSH), superoxide dismutase (SOD), catalase (CAT), carcinoembryonic antigen (CEA) and ferritin (SF) level changes and adverse reactions .Results Recently, the total efficiency of observation group was significantly higher than the control group (82.4%vs.55.8%,χ2 =4.533, P =0.033).After chemotherapy, the levels of NO, MDA, GSH, SOD, CAT, CEA and SF in the 2 groups were significantly higher than those in the control group ( t =5.648, t =5.187, t =1.723, t =2.157, t =1.848, t =4.553, P <0.05).During the period of chemotherapy in pa-tients with adverse reactions of 2 groups were neutropenia, nausea /vomiting, leukopenia, thrombocytopenia, low hemoglo-bin, hair loss, fatigue, low albumin, liver function damage, joint and muscle pain and cardiac toxicity , there was no signifi-cant difference between the 2 groups (χ2 =0.197,χ2 =1.619,χ2 =0.188,χ2 =0.197.χ2 =0.188,χ2 =0.188,χ2 =0.188,χ2 =0.924,χ2 =0.188,χ2 =0.706,χ2 =0.240, P >0.05).Conclusion Application of breast cancer patients with FAC regimen have curative effect , oxidative stress in the body is relatively light , and the adverse reactions could be tolerated , it can be used as one of the chemotherapy of patients with breast cancer .
Keywords：5 fluorouracilCyclophosphamideAdriamycinBreast carcinomaOxidative stress
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 377-380,384 )