Relationship between serum SFPR5 level and insulin resistance in patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease
ZHANG Li
LUO Li
LU Chunhui
ZHANG Jie
LI Xiaolan
Abstract：Objective To investigate the relationship between serum levels of secreted type 5 ( SFRP5) and insulin resistance ( IR) in patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease ( NAFLD) .Methods We selected 45 patients with type 2 diabetes from February 2015 to February 2016 in the Fifth Affiliated Hospital of Xin-jiang Medical University, they were included DM group , NAFLD group, DM+NAFLD group, 50 healthy volunteers were taken as control group (NC group).Physical fitness test, serum SFRP5, fasting blood glucose (FPG), fasting insulin ( FINS) and other biochemical indicators were tested .Pearson and multiple linear regression were used to analyze the correla-tion between serum SFRP5 level and BMI, TC, TG and other indicators.Results Each group of subjects' sex, age, systolic blood pressure and diastolic blood pressure had no significant difference ( F =1.406, F =1.204, F =2.044, F =1.946, P >0.05), NAFLD group and DM +NAFLD group' s BMI were significantly higher than that of NC group and DM group (F =8.391, P =0.022);SFRP5:DM+NAFLD group <DM group <NAFLD group <NC group ( F =11.283, P =0.000);insulin resistance index ( HOMA-IR): NC group <NAFLD group <DM group <DM+NAFLD group ( F =10.012, P =0.000);FPG, glycosylated hemoglobin (HbA1c), FINS, total cholesterol (TC), three glycerol (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) showed no significant differences (F =10.391, F =9.213, F =10.832, F =8.743, F =9.111, F =8.948, F =9.472;P <0.05);the serum levels of SFRP5 and BMI, FPG, HbA1C, TC, TG, LDL-C and HOMA-IR were negative related ( r =-0 .302, r =-0.401, r =-0.464, r =-0.221, r =-0.280, r =-0.321, r =-0.282, P <0.05); multiple linear stepwise regression analysis showed that HOMA-IR was an independent factor of serum SFRP 5.Conclusion The level of serum SFPR5 in patients with type 2 diabetes mellitus combined with NAFLD was significantly decreased , which was negatively correlated with insulin resis-tance.
Keywords：Diabetes mellitustype 2Non alcoholic fatty liver diseaseSecreted frizzled related protein 5Insulin resistance
Publication Date：2017-01-01
Pages：4( 360-363 )