Therapeutic effect of thoracoscopic repair on patients with atrial septal defect and the serum levels of TNF-α, IL-6, ICAM-I and cTnI
TIAN Zexiang
LIU Zhiping
WANG Jian
LI Shuzhen
Abstract：Objective To study the effect of endoscopic repair in the treatment of patients with atrial septal defect and the effect of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), serum cell adhesion molecules (ICAM-I), car-diac troponin I (cTnI).Methods From March 2014 to February 2016, according to the order of admission , 78 patients with atrial septal defect were divided into observation group and control group .The observation group was used to complete the re-pair under thoracoscopy , and the control group was treated with conventional median thoracotomy .The changes of TNF-α, IL-6, ICAM-1 and cTnI were compared between the two groups before and after operation .Results The aorta block time and ex-tracorporeal circulation time of the observation group were significantly longer than those in the control group [(25.43 ±2.43) min vs.(18.96 ±1.23) min,(65.43 ±5.32) min vs.(41.58 ±4.03), t =14.835, t =22.317, P =0.000], the intraop-erative blood loss was significantly less than the control group [(142.54 ±14.67) ml vs.(187.48 ±18.54) ml, t =11.871, P <0.01], the difference was statistically significant ( P <0.05).The hematocrit and hematocrit of the two groups had no significant difference ( P >0.05).The time of ventilator assistance, the amount of blood transfusion, the amount of drainage and the length of hospital stay were significantly lower in observation group than those in control group ( P <0.05).The lev-els of TNF-α, IL-6, ICAM-1 and cTnI in the observation group after surgery were significantly lower than those in the control group[(3.23 ±0.31) μg /L, (134.32 ±13.45) μg /L, (287.32 ±21.43) L, (2.75 ±0.23) μg /L vs.(4.39 ±0.46)μg /L, (174.32 ±15.32) μg /L, (314.21 ±32.05) ,(3.23 ±0.42)μg/L, t =13.060, t =12.253, t =4.356, t =6.260, P <0.01].Conclusion It suggested that the thoracoscopic repair in patients with atrial septal defect had little in -fluence on the severity factor level of patients , with mild body tissues and myocardial damage , as well quickly recovery and effective operation .
Keywords：Thoracoscopy repairAtrial septal defectTumor necrosis factor-αInterleukin-6Intercellular adhesion molecule 1Cardiac troponin Ⅰ
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 348-351 )