Effects of bisoprolol on norepinephrine epinephrine and angiotensin in patients with chronic heart failure

LI Haili; LIN Kaiyao; ZHENG Weimin; ZHAO Shengjie

doi:10.3969/j.issn.1671-6450.2017.04.004

Abstract：Objective To study the effects of bisoprolol on norepinephrine epinephrine and angiotensin in patients with chronic heart failure .Methods 56 patients with mild to moderate chronic heart failure diagnosed in the hospital from March 2013 to March 2016 were selected as heart failure group and another 30 normal subjects as control group .Heart failure was randomly divided into two subgroups ( n =28).The first group taking bisoprolol at 7:00-8:00, the second group taking bisoprolol at 19:00-20:00;before treatment and 4 weeks after treatment, respectively, dynamic electrocardiogram,adrenaline and angiotensin Ⅱ(AngⅡ) were measured at 2:00,6:00,14:00,18:00 and 22:00.Results The NE, epinephrine and an-giotensin in chronic heart failure patients were higher than those in the normal control group at 6:00,10:00,14:00,18:00, 22:00, and 2:00( F =16.325, P =0.000).Circadian rhythm disappeared after cosine-fit method.The heart rate was posi-tively correlated with NE, epinephrine and angiotensin ( P <0.05).The levels of NE, epinephrine, and angiotensin were sig-nificantly lower in patients with HF than those in the control group ( F =7.856, P <0.05) at all time points, but the circa-dian rhythm abnormality did not recover .There was no significant difference between before and after treatment ( t =2.856, P =0.135).Conclusions Chronic heart failure patients with 24-hour heart rate and norepinephrine , epinephrine and angio-tensin Ⅱ and other factors circadian rhythm abnormalities .Bisoprolol at different time could reduce the heart rate and the lev-els of norepinephrine ,epinephrine and angiotensin II in chronic heart failure patients , but had no significant effect on circadian rhythm.