The curative effect of levosimendan in patients with chronic heart failure and the influences on cTNT,IGF-1 and oth-er cytokines level

DONG Qingfeng; ZHAO Dong; ZHOU Wei; WANG Lei

doi:10.3969/j.issn.1671-6450.2017.04.003

Abstract：Objective To The curative effect of levosimendan in patients with chronic heart failure and the influences on Cardiac troponin T(cTNT) andInsulin-like growth factor-1((IGF-1) and other cytokines level.Methods 114 cases of pa-tients with chronic heart failure from June 2014 to June 2014 were treated , wich from Liaoning Jinqiu Hospital geriatric medi-cine two wards,according to the draw method divided into control group and the observation group , each have 57 cases, control group routine therapy, the observation group based on control group joint leosimendan , two groups' of cTNT and ICF-1 level, N terminal brain natriuretic peptide precursor ( NT-proBNP ) , inflammatory factor and oxidative stress levels , hemodynamics and cardiac function index, safety were compared.Results After treatmented, the cTNT (66.39 ±15.32) ng/L of observa-tion group was lower than the control group (77.83 ±18.20) ng/L, the IGF-1 (138.60 ±18.240) μg/L of observation group was higher than the control group (121.46 ±15.32) μg/L, the difference was statistically significant ( t =3.630、5.432, P =0.000,0.000).The NT-proBNP (4049.87 ±452.30 ) ng/L of observation group was lower than the control group (4276.94 ±483.96) ng/L, the difference was statistically significant ( t =2.588, P =0.000).The inflammatory factor and oxidative stress level of observation group was improved more significantly ( P <0.05).The hemodynamic index of obser-vation group was better than the control group ( P <0.05).The cardiac function index of two groups was no statistical differ-ence ( P >0.05).The security of two groups was no statistical difference ( P >0.05).Conclusion Levosimendan in treat-ment of chronic heart failure can reduce the level of cTNT and IGF-1.