Analysis of common causes and risk factors of chronic cough in children：report of 279 cases

WENG Zelin; JIANG Wenwen; ZHENG Yanxia; XU Youjia

doi:10.3969/j.issn.1671-6450.2017.02.017

Abstract：Objective To sum up the common causes of chronic cough in children , and to explore the risk factors of chronic cough .Methods Two hundred and ninety-five children with chronic cough who treated in Guangdong Province Tra-ditional Chinese Medical Hospital from November 2012 to October 2015 were enrolled, and 16 cases were excluded from the inclusion criteria , the rest of patients with chronic cough were divided into 3 groups according to their age , including the infant group, the preschool group and the school age group .Through the prospective clinical research methods , diagnosis was made according to the diagnostic procedure of chronic cough .Through single factor analysis to determine the difference between the three groups of different causes of the relevant factors , through the multi factor non conditional Logistic regression analysis to explore the risk factors of UACS, CVA and PIC.Results 279 cases of chronic cough etiology:UACS 79 cases (28.31%), CVA 91 cases(32.62%), PIC 90 cases (32.26%), 19 cases (6.81%); for sick infants were mainly caused by PIC , the constituent ratio of roughly the same of the 3 factors in preschool group , school-age mainly caused by CVA .A common cause of chronic cough in the situation analysis showed that sex , tobacco, environmental exposure and 31 factors have significant difference in different etiology group ( P <0.05); by multi factor non conditional Logistic regression analysis showed that UACS risk factors include family smoking (tobacco exposure), daytime cough, decubitus cough and nasal obstruction ( P <0.05);CVA risk factors include family history of allergic rhinitis , family history of asthma , cold air or odor stimulation , aller-gens ( P <0.05);PIC’s risk factors including climate change factors and antibiotic use ( P <0.05).Conclusion The eti-ology of chronic cough was different in different age groups , and the same causes were different in different age groups .The clinical features can provide clues for the diagnosis of chronic cough .UACS risk factors , including family members of smoking (tobacco exposure), cough during the day, the sleeping position, cough, nasal obstruction;CVA risk factors include family history of allergic rhinitis , family history of asthma , cold air or odor stimulation , allergen;PIC risk factors, including climate change factors and the use of antibiotics .