Effect of oxycodone pretreatment in the fracture postoperative analgesia
DENG Xuefeng
ZHU Yanhao
CHANG Qimin
LENG Minghao
CHEN Kang
Abstract：Objective To analyze the effects of oxycodone preconditioning on postoperative analgesia in fracture . Methods From March 2012 to July 2015, in Anhui University of Traditional Chinese medicine , the First Affiliated Hospital, 98 cases underwent elective surgery under general anesthesia in Department of orthopedics patients , according to admission or-der number , they divided into control group and observation group with 49 cases in each group , 2 groups were given analgesic treatment, the control group was treated with fentanyl intervention , observation group used oxycodone hydrochloride injection intervention, 2 groups of patients were compared with extubation (T1), extubation 5min (T2), extubation 0.5h (T3) and heart rate (HR), systolic blood pressure (SBP), sedation (Ramsay) score changes, using visual analogue scale (VAS) to assess of postoperative 2 h, 4 h, 6 h, 12h, 24 h, H 2 groups of pain, preoperative, postoperative 24 h patients with interleu-kin 6 (IL 6), tumor necrosis factor alpha (TNF alpha) levels, statistical postoperative incidence of adverse events .Results (1) T1, T2 time, 2 groups had no statistically significant differences of HR , SBP, Ramsay score ( P >0.05), T3 SBP, HR of the observation group lower than in the control group , Ramsay score higher than the control group ( P <0.05);(2) 2 h after the operation, the 2 groups’ rest of the time points’ VAS scores were increased ( F =19.304, F =15.227, P =0.000),but different time points after surgery of the observation group ’s VAS scores were lower than the control group ( t =18.783, t =11.649, t =13.590, t =11.200, t =21.913, P =0.000);(3) compared with the same group before opera-tion, IL 6 and TNF alpha level increased in both of 2 groups 24 h after surgery, the difference was statistically significant (ob-servation group:t =5.840, t =5.079, P <0.05; control group:t =11.908, t =11.238, P =0.000), the observation group increased degree significantly lower than the control group ( t =6.773, t =8.170, P <0.05);(4) the incidence rate of adverse reaction and complication of the 2 groups showed no differences statistical significance ( P >0.05).Conclusion Oxycodone analgesia for pretreatment of orthopedic surgery can reduce postoperative pain , stable hemodynamics , reduce in-flammatory reaction , and with high safety .
Keywords：Fracture surgeryOxycodonePostoperative analgesiaEffect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 168-171 )