Relationship between serum FABP4, chemerin, Nesfatin-1 and insulin resistance and beta cell function in patients with gestational diabetes mellitus
SHEN Lifang
SONG Ge
HUANG Qing
PEI Jiong
Abstract：Objective To analyze the relationship between fatty acid binding protein 4 ( FABP4 ) , chemokine (chemerin), and dietary inhibitory factor (Nesfatin-1) and insulin resistance and beta cell function in patients with gestation-al diabetes mellitus (GDM).Methods From June 2013 to October 2015, 50 GDM patients (GDM group) admitted to the first people's Hospital of Changshou City of Jiangsu province Department of Endocrinology were enrolled as the research object , the other 40 cases of healthy pregnant women as control group , 2 groups of serum FABP4,chemerin, Nesfatin-1 levels and IR and beta cell function index were compared .Results The levels of FABP4, chemerin and Nesfatin-1 in the GDM group were significantly higher than those in the healthy control group [(35.11 ±11.32) μg /L vs.(21.14 ±8.75) μg/L, (8.41 ± 3.33) mg/L vs.(2.86 ±0.74) mg/L, (4.99 ±1.61) μg/L vs.(2.01 ±0.44) μg/L, t =2.559, t =2.224, t =2.112, P =0.008, P =0.017, P =0.021].The levels of HOMA-IR, HOMA-β, INSAUC /PGAUC and△I30 /△G30 in GDM group were lower than those in healthy control group [(2.12 ±0.66) vs.(3.74 ±1.29), (165.32 ±24.45) vs.(102.27 ± 24.12) ,(10.81 ±3.95) vs.(8.01 ±3.32),(21.51 ±4.98) vs.(15.91 ±6.33), t =2.056,2.840,2.392,2.616, P =0.024, P =0.004, P =0.011, P =0.007].FABP4, chemerin and Nesfatin-1 were positively correlated with HOMA-IR (r =0.422, r =0.379, r =0.345, P <0.05), and negatively correlated with HOMA-β( r =-0.466, r =-0.312, r =-0.326, P <0.05).Conclusion The levels of FABP4, chemerin, Nesfatin-1 were significantly increased in patients with GDM, and there was some correlation between IR and pancreatic beta cell function .
Keywords：Fatty acid binding protein 4ChemokineFood inhibitory factorGestational diabetes mellitusInsulin resistanceBeta cell function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 160-163 )