Therapeutic effect of prednisone and Guilongtongluo capsules on chronic inflammatory demyelinating polyneuropathy

ZHOU Jin; SUN Yuhua; HAN Yi; WANG Bing; LI Xiaoyan; LIU Xiao

doi:10.3969/j.issn.1671-6450.2017.02.006

Abstract：Objective To explore the clinical effect of prednisone combined with Guilongtongluo capsules in the treatment of chronic inflammatory demyelinating polyneuropathy .Methods A total of 76 cases from January 2012 to February 2015 in Dalian University Affiliated Xinhua Hospital which were diagnosed and received the treatment of chronic inflammatory demyelinating polyneuropathy patients were randomly divided into control group ( given prednisone tablets 15 mg/d) and ob-servation group ( given prednisone tablets 15 mg/d+Guilongtongluo capsules 6 pills /time, 3 times /d) with 38 cases in each group .The clinical efficacy of the 2 groups before and after treatment of upper limb distal and proximal , distal and proxi-mal lower limb muscle strength were observed;the EMG /evoked potential were examined in 2 groups of patients before and after treatment of ulnar nerve , common peroneal nerve motor nerve conduction velocity ( MCV) , distal latency ( ML) and sen-sory nerve conduction velocity ( SCV) were evaluated before and after treatment , the motor function and sensory function , the evaluation of the ability of daily life of patients with Barthel index ( ADL) changes and adverse reactions during treatment were compared.Results The total efficiency of the observation group was significantly higher than the control group (92.11%vs. 68.42%,χ2 =6.79, P =0.03).After treatment, 2 groups of patients with upper limb distal and proximal , distal and proxi-mal lower limb muscle strength was significantly higher than before treatment (Control group:t =9.76, t =6.99, t =7.85, t =4.69, P <0.01,observation group:t =8.36, t =7.82, t =8.02, t =5.82, P <0.01), and the observation group was higher than that of the control group ( t =11.02, t =10.22, t =6.68, t =11.14, P <0.01).2 groups of patients with ulnar nerve and common peroneal nerve MCV , SCV higher than that before treatment , ulnar nerve and peroneal nerve ML was significantly lower than that before treatment , and the observation group MCV , SCV higher than the control group , ML was lower than the control group ( t =6.17, t =7.77, t =7.98, t =6.51, t =4.96, t =7.18, P <0.01).The scores of motor function and sensory function of the 2 groups were lower than those before treatment , while the scores of the observation group after treatment were lower than those of the control group ( t =9.36, t =6.72, P <0.01).2 groups of patients after treat-ment ADL score was significantly higher than before treatment ( t =4.36, t =5.24, P <0.05), the observation group after treatment ADL score was significantly higher than that of the control group ( t =9.66, P <0.01);2 groups had no significant adverse reactions during treatment .Conclusion Prednisone combined with Guilongtongluo capsules in the treatment of chron-ic inflammatory demyelinating polyneuropathy has a significant effect and safety .