A study of the concentration of haptoglobin in serum before and after Huashixingyuqingre decoction in treatment of oral lichen planus
GUO Feng
ZHANG Meijie
XU Yanzhi
LIU Fengying
LIU Shanshan
CHEN Si
DUAN Yanhao
YA0 Manman
Abstract：Objective To observe the therapeutic effect of self-made Huashixingyuqingre decoction ( HXQD) on o-ral lichen planus ( OLP) , and the effect on the serum haptoglobin concentration and the level of peripheral blood T lymphocyte subsets.Methods From October 2013 to May 2015, 42 OLP patients were collected from Department of Stomatology , the fourth hospital of Hebei Medical University and the first outpatient department of directly departments of Hebei Province .The subjects were divided into 2 groups, treatment group and control group , each group having 21 individuals.Both groups were given conventional treatment , the basal parts of oral lesions in control group were sealed by cod liver oil topical application and triamcinolone acetonaide acetate injection , while treatment group were given Huashixingyuqingre decoction .The serum hapto-globin concentration and the changes of peripheral blood T lymphocyte subsets before and after treatment were detected , and curative effects of two groups were compared .Results The total effective rate of treatment group was 90.5%, which was sig-nificantly higher than the control group ’s 61.9%(χ2 =4.725, P <0.05); After 8 weeks of treatment, the serum Hp con-centration of the treatment group was higher than that before treatment ( t =3.933, P <0.01), which higher than that in the control group as well ( t =2.247, P <0.05).After 8 weeks of treatment, peripheral blood CD3 +, CD4 +in two groups were not only higher than before treatment ( P <0.01), but also higher than the control group ( t =5.170, t =4.402, P <0.01).Although peripheral blood CD8 +and CD4 +/CD8 +were higher than before treatment, the difference was not statisti-cally significant ( P >0.05).Conclusions The HXQD has a certain curative effect on oral lichen planus , the serum hapto-globin concentration and changes of peripheral blood T lymph subsets , it may have some effect on the occurrence and develop-ment of oral lichen planus as well .
Keywords：Oral lichen planusHuashixingyuqingre decoctionHaptoglobinSerumT lymphocyte subsetsPerip-heral blood
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 68-71 )