Changes in thyroid hormone and bone mineral density of elderly patients with Graves ’ disease in treatment with levothyroxine and methimazole
LI Zhen
OU Daoliang
LI Meihua
ZHONG Chunzheng
Abstract：Objective To observe the effect of levothyroxine combined with methimazole treatment of elderly patients with Graves’ disease on thyroid hormones and bone mineral density index .Methods Sixty cases of elderly patients with Graves ’ disease were selected , who were treated in hospital from February 2014 to February 2015 , and they were divided into the study group (30 cases) and the control group (30 cases).The patients of control group were treated with methimazole tab-lets (2 times /day, initial dose of 20-30 mg /d, after treatment of one month , review of thyroid function monthly , gradually reduce the dose adjustment).On the basis of control group, the patients of study group were treated with levothyroxine (25g/d, orally, 2 times /day, review of thyroid function monthly ).The patients of two groups were all consecutive treated for 12 months.Compare the thyroid function , bone biochemical markers , bone mineral density and the incidence of adverse reactions of two groups.Results After the appropriate treatment, the levels of FT3, FT4, TRAb, TPOAb, BGP, ALP, UP, UCa of the study group were significantly lower than those of the control group ( t =7.705, t =1.743, t =2.783, t =1.762, t =8.625, t =10.128, t =33.495, t =8.207, t =1.730, P <0.05), the levels of TSH of the study group were significantly higher than those of the control group ( t =1.730, P <0.05), but in the terms of PTH, CT, there were no significant differ-ence between the two groups ( t =0.224, t =0.278, all P >0.05);The bone mineral density of femoral neck , lumbar L2-L4, femoral trochanter , Ward triangle bone of the study group were significantly higher than those of the control group ( t =3.701, t =3.215, t =3.277, t =1.856, all P <0.05); There were rash, leukopenia, agranulocytosis, gastrointestinal tract, liver damage and other adverse reactions occurred in both two groups during the treatment , but there was no significant difference between the two groups (χ2 =0.712,χ2 =0.529,χ2 =1.940,χ2 =1.217,χ2 =2.420, all P >0.05).Conclu-Levothyroxine combined with methimazole treatment can effectively improve the level of thyroid hormone in elderly pa -tients with Graves ’ disease , increase bone density , good safety , and is worthy of clinical promotion .
Keywords：LevothyroxineMethimazoleGraves’ diseaseThyroid hormoneBone mineral density
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 56-59 )