Therapeutic effect of noninvasive ventilation combined with naloxone for treating chronic obstructive pulmonary di-sease with acute exacerbation combined with type Ⅱrespiratory failure
SHAO Boyun
ZHOU Weihua
ZHU Bojin
LI Xiaolong
Abstract：Objective To investigate the efficacy and clinical experience of using noninvasive ventilation combined with naloxone for treating chronic obstructive pulmonary disease ( AECOPD) with acute exacerbation combined with type Ⅱre-spiratory failure.Methods From January 2013 to December 2015, in People Hospital of Hai ’ an County, 90 patients with AECOPD combined with type Ⅱrespiratory failure were chosen as research subjects , according to the method of treatment , they were randomized into observation group ( n =52 ) and control group ( n =38 ); control group received conventional treatment , observation group received noninvasive ventilation on its basis combined with naloxone treatment , then observing ef-ficacy and clinical experience .Results The total effective rate in the observation group was significantly higher than that in the control group (98.1% vs.79.0%,χ2 =8.927, P =0.003).After treatment, the degree of improvement of clinical symptoms such as respiratory rate , heart rate, FEV1/FVC% and dyspnea score was much better than control group ( t =6.668, t =6.272, t =6.192, t =6.597, all P <0.05).The degree of blood analysis index improvement of SPO 2,PaO2, PaCO2 , pH in observation group was significantly better than that in the control group ( t =6.616, t =6.931, t =6.315, t =6.219,all P <0.05).The tracheal intubation rate and the exacerbation rate within 6 months were significantly lower in obser-vation group than that in control group (χ2 =6.583,χ2 =6.467, all P <0.05).There was no significant difference in the in-cidence of adverse reactions between two groups (χ2 =1.134, P =0.102).Conclusion Using noninvasive ventilator joint naloxone to treat AECOPD patients with type Ⅱrespiratory failure can significantly improve the clinical symptoms , activity tol-erance and heart and lung function , improve the quality of patients ’ lives and reduce the invasive ventilator utilization and re-duce the frequency of exacerbation .It is of high security , and worthy of promotion and application in clinical practice .
Keywords：Noninvasive ventilationNaloxoneCchronic obstructive pulmonary disease with acute exacerbationType Ⅱrespiratory failureTherapeutic effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 40-43 )