The effect of tumor necrosis factor alpha and interleukin-6 of benazepril combined wit h spironolactone in patients with heart failure
XU Shanshan
HU Hanchen
YING Zuochen
GAO Qin
ZHU Dan
GAO Xinsuo
Abstract：Objective To observe the curative effect of lotensin combined with spironolactone in the treatment of pa -tients with heart failure and effect on tumor necrosis factor alpha ( TNF-α) and interleukin 6 ( IL-6) .Methods From Novem-ber 2014 to October 2015 , selecting 66cases of patients with heart failure in Qinghai cardiovascular and cerebrovascular dis -ease hospital ,department of arrhythmia , according to the method of random numbers , all the patients were divided into obser-vation group and control group , 33 cases in each group .Control group were treated with conventional drugs with Benazepril for treatment, observation group on the basis of control group were given spironolactone for treatment .Compared the two groups before and after five months of treatment with left ventricular end systolic diameter ( LVESD) , left ventricular end diastolic di-ameter ( LVEDD) , left ventricular ejection fraction ( LVEF) , 5 minutes walking distance , tumor necrosis factor alpha ( TNF-α), interleukin 6 (IL-6) level changes, and adverse reaction.Results After treatment, the clinical curative effect of obser-vation group was significantly higher than the control group (87.88%vs.60.61%,χ2 =6.418, P =0.011).Compared with before treatment, after treatment of the 2 groups of TNF-α, IL-6, LVESD, alpha 6 LVEDD decreased, LVEF, 5 min walking distance were increased ( P <0.05); and after treatment the observation group TNF-α, IL-6 level was significantly lower than the control group[(6.57 ±0.61) ng/L vs.(7.86 ±0.76) ng/L,(29.43 ±2.45) ng/L vs.(38.65 ±3.54) ng/L, t =7.604, t =12.303;P <0.05].LVESD and LVEDD were significantly lower than the control group [(43.54 ±3.08)mm vs.(47.05 ±3.25) mm, (51.24 ±4.57) mm vs.(56.54 ±5.02) mm, t =4.503, t =4.485, P <0.05], LVEF and 5 min walking distance was significantly higher than that of control group [(45.54 ±4.87)% vs.(38.54 ±4.05)% and (282.54 ±25.42) m vs.(252.32 ±22.54) m, t =6.349, t =5.110, P <0.05].Conclusion Lotensin combined with spironolactone can effectively reduce heart failure in patients with TNF -α, IL6-, LVESD, LVEDD level, increased LVEF level with high security .
Keywords：BenazeprilSpironolactoneHeart failureTumor necrosis factor-αInterleukin-6
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )