The value of detection of the prognosis of gastric cancer patients by the detection of the antigen of ascites and the de-tection of cell keratin:A Meta analysis
LI Chengbiao
WANG Yupei
LEI Jinhua
Abstract：Objective To evaluate of the prognosis of patients with gastric cancer by systematic review of ascites cancer embryo antigen (CEA) and cell keratin (CK20).Methods We searched literature concerning studies on the prognos-tic significance of peritoneal fluid detection of CEA or CK 20 in gastric cancer patients from PubMed , Cochrane Library , Em-base, CNKI, Wanfang database with the time range of searching set from establishment of the databases to March 2016.Meta analysis was conducted using the Cochrane Collaboration's RevMan 5.2 software.Results A total of 11 articles met criteria were included in the study .A total of 1 221 patients were enrolled .The results of Meta analysis showed that compared with as-cites CEA/CK20 positive group and CEA/CK20 negative group postoperative survival rate significantly improved (HR=0.84, 95%CI 0.78-0.90, P <0.01); disease free survival rate showed no significant difference (HR=1.19, 95%CI 0.93-1.52, P =0.17);no peritoneal recurrence survival rate improved significantly ( HR=0.87, 95%CI 0.76 -0.98, P =0.02);subgroup analysis showed that CEA and CK 20 combined detection of the long-term prognosis of patients with gastric cancer is better than that of single CEA detection value judgment .Conclusion For patients with gastric cancer , in the early stage of disease to carry out CEA and CK 20 detection of ascites , to provide reference for the choice of surgical methods and postoperative treatment , can effectively improve the long-term survival rate of patients .
Keywords：Gastric carcinomaAscitesTumor antigenKeratinPrognosisMeta analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1279-1283 )