Clinical research on the effect of Tongxinluo capsule in patients with senile dementia

ZHANG Zhihui; JIA Zhenhua; AN Junqi; SUN Yonghui

doi:10.3969/j.issn.1671-6450.2016.12.017

Abstract：Objective To observe the therapeutic effect of Tongxinluo capsule on senile cognitive dysfunction and its effect on cerebral blood flow , nitric oxide and endothelin .Methods From January 2012 to January 2016 , 120 cases of elderly patients with cognitive impairment in Hebei Yiling hospital diagnosis and treatment of encephalopathy were enrolled as the re -search object, they were randomly divided into treatment group with 60 cases, according to TCM syndrome , they were given Tongxinluo capsule, 60 cases in control group were given Ginkgo Biloba Leaves Extract Tablets , treatment duration were 3 months .Clinical efficacy , cerebral blood flow and changes of endothelin and nitric oxide were observed in 2 groups of patients before and after treatment using simple mental state simple speed test ( MMSE) and daily life self care scale ( ADL) .Results The overall efficacy in treatment group was higher than that of control group (90.0%vs.70.0%,χ2 =7.500, P =0.006), improving MMSE and ADL score of the Tongxinluo group were better than that of Ginkgo biloba group (MMSE:t =-3.005, P =0.003;ADL:t =-5.476, P =0.000), cerebral blood flow improvement showed significant difference between the 2 goups ( t =3.400, P =0.001) , improvement of the nailfold microcirculation in Tongxinluo group was better than that of Ginkgo biloba group, there was significant difference ( t =3.775, P =0.000;t =3.534, P =0.001;t =2.810, P =0.006;t =3.090, P =0.003), nitric oxide improvement of Tongxinluo group was better than that of Ginkgo biloba group (t =1.159, P =0.132;t =-2.442, P =0.016).Conclusion The therapeutic effect of Tongxinluo in the treatment of se-nile cognitive dysfunction is better than that of Ginkgo biloba , especially in the protection of cerebral circulation , which may be one of the ways to treat cognitive dysfunction in the elderly .