The clinical effect of hydroxychloroquine sulfate combined with prednisone in the treatment of oral lichen planus
XIA Haixia
Liuyang
YUAN Runyu
WU Xiangbing
REN Wei
Abstract：Objective To observe the clinical effect of hydroxychloroquine sulfate combined with prednisone in the treatment of oral lichen planus .Methods Selected 84 cases of oral mucosal lichen planus patients in our hospital from January 2014 to 2016 January as the research subjects , according to the order of treatment , they were randomly divided into two groups, each group of 42 cases, the control group treated with prednisone treatment , even as the study group, the use of hydroxychloroquine sulfate combined with prednisone in the treatment .Compared two groups of patients with clinical curative effect observed after 4 weeks of continuous treatment , recurrence, pain and adverse reactions occurrence .Results Patients in the study group, the total efficiency was significantly higher than control group (95.65% vs.78.26%,χ2 =6.133, P <0.05).The 3 month study group of patients after treatment of the recurrence rate and the control group had no significant difference (8.70%vs.2.17%,χ2 =1.903, P =0.167);but the study group patients after 6 and 12 months recurrence rate was significantly lower than the control group (8.70% vs.26.09%,13.04% vs.39.13%, χ2 =4.842, P =0.027;χ2 =8.118, P =0.004).No statistically significant differences in VAS scores between the 2 groups of patients before treatment , [(5.37 ±1.42) vs.(5.45 ±1.32), t =0.345, P >0.05], 2 groups of patients after treatment , VAS scores were lower than those before treatment ( P <0.05);patients in the study group after treatment VAS score was significantly lower than the control group (2.24 ±0.86) vs.(3.86 ±1.12), t =9.598, P =0.000.The adverse reaction of patients in the study group during the treatment of the total incidence rate was significantly lower than the control group (8.70% vs.23.91%,χ2 =3 .903, P =0.048).Conclusion Oral lichen planus treated with hydroxychloroquine sulfate and prednisone can significantly improve the therapeutic effect , reduce the pain degree of patients , reduce the incidence of adverse reaction , recurrence rate and medication is safe and reliable , can be applied in clinical work .
Keywords：Hydroxychloroquine sulfatePrednisoneOral mucosa platform mossClinical curative effect
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1268-1270,1283 )