Retrobulbar injection of triamcinolone acetonide combined with retinal photocoagulation in treatment of diabetic macular edema curative effect observation
ZHANG Dawei
ZHANG Rui
YANG Min
KONG Fanhong
Abstract：Objective To investigate the efficacy and safety of peribulbar injection of triamcinolone acetonide ( perib-ulbar TA) on diabetic retinopathy with macular edema before laser photocoagulation .Methods Forty six eyes with severe non proliferative unilateral diabetic retinopathy were divided into an experimental group ( received a single peribulbar TA be-fore laser photocoagulation, TA group) and a control group (received laser photocoagulation only).The best corrected visual acuity (BCVA), the change of intraocular pressure (IOP) and central macular thickness (CMT) were measured before and after treatment in 6 months.Results The follow up period were six months .BCVA in TA group at the 1 month and 3 month was better than that before treatment , the change had significant difference ( P <0.05), and correspondingly CMT reduced significantly( P <0.05);BCVA in control group at the 1 month and 3 month was worse than that before treatment and the change had significant difference ( P <0.05), and CMT increased correspondingly more than that before treatment;At the 1 month and the 3 month follow up, the changes of the BCVA between two groups had significant differences ( P <0.05), and the visual acuity in TA group was much better than that in control group;CMT in TA group at the 1 month reduced more sig-nificantly than that in control group , and the change had significant difference ( P <0.05).The changes of IOP in TA group or in control group were normal before and after treatment , but IOP in TA group at the 1 month was higher than that in control group( P <0.05).Only one patient in TA group (focal macular edema) show that fluorescein leakage of peripheral retina and macular dilated capillary disappeared completely when re-examination of fluorescein fundus angiography ( FFA) after treat-ment in 2 or 3 month.Conclusion The combination of TA and PRP in the treatment of diabetic retinopathy is more effective than the simple PRP treatment .It can improve visual acuity and reduce macular edema in a short time .2-3 months to review the FFA, and then give supplementary laser photocoagulation treatment .
Keywords：Peribulbar injectionTriamcinolone acetonideLaser photocoagulationDiabetic retinopathyMacular edema
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1263-1267 )