The impact of plasma LPA, Hcy and P-selectin of breviscapini in deep venous thrombosis therapy
BAI Dou
JIANG Lanshan
WU Shaohui
ZHANG Xiaojie
ZHENG Jiali
Abstract：Objective To investigate the effect the impact of plasma phosphorus fatty acid (LPA), homocysteine ( Hcy) , P-selectin in breviscapini treatment of deep venous thrombosis .Methods One hundred and twenty cases of patients with DVT were divided into observation groups ( n =60 ) and control group ( n =60 ) from June 2015 to June 2016 .Two groups were arranged with absolute bed rest , limb elevation.The control group were treated with subcutaneous heparin 100 U/kg, 2 times a day, 7 days of treatment to oral warfarin, according to international normalized ratio (INR) adjusted warfarin. Observation group were treated with intravenous Dengzhanhua 40 ml+5%glucose 250 ml, sustained 14 days of treatment to oral warfarin, adjusted according to INR warfarin .The clinical results and complications of two groups were compared .The re-canalization rate, hemorheology and the levels of plasma LPA , Hcy, P-selectin were observed before and after treatment .Re-sults The observation group at 7 d and 14 d after femoral vein , popliteal vein , posterior tibial vein thrombosis recanalization rate was significantly higher than the control group (χ2 =7.500,χ2 =5.566,χ2 =4.444,χ2 =8.086,χ2 =6.171,χ2 =8.107, P <0.05);the observation group of plasma activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) were better than the control group ( F =242.52, F =232.69, F =202.69, P <0.05);plasma LPA, Hcy and P-selectin significantly decreased compared to the control group ( F =245.36, F =315.22, F =342.66, P <0.05).The complication rate was lower than the control group (χ2 =5.926, P =0.015).Conclusion Breviscapine injection can im-prove the recanalization rate of thrombosis in patients with DVT , improve the coagulation indexes of patients , reduce the plas-ma LPA, Hcy and P-selectin is safe and effective , worthy of clinical application .
Keywords：Breviscapini injectionLower limb deep vein thrombosisClinical efficacyPhosphorus fatty acidHomo-cysteineP-selectin
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1255-1258 )