Clinic results and changes in inflammatory cytokines, adhesion molecules of patients with hypertension and diabetes in treatment with telmisartan
HUANG Ying
HAO Yanli
SUN Ying
ZHANG Huiying
Abstract：Objective To observe the effect and influence of telmisartan on inflammatory cytokines and adhesion mol -ecules in hypertensive patients with diabetes .Methods Eighty-six cases of patients with hypertension and diabetes were se-lected, which were treated in hospital from February 2015 to February 2016, and they were divided into the observation group (43 cases) and control group (43 cases).The patients of two groups were all treated with low sodium salt restriction , high protein diet and glycemic control ( continuous oral hypoglycemic agents or administration of insulin ) .The patients of control group were treated with levamlodipine (2.5 mg /time, morning service for 1 time /d).On the basis of control group, the patients of observation group were treated with telmisartan (40 mg /time, morning service for 1 time /d).The patients of two groups were all treated with continued 12 weeks.Compared the adverse reactions and changes of the levels of FINS , FPG, HbA1c,CRP, IL-6, IL-8, TNF-α, VCAM-1, ICAM-1 of two groups.Results After the appropriate treatment, the patients of the observation group got a total effective rate of 90.7%, which was significantly better than the 74.4% of the control group (χ2 =3.957, P =0.047);The levels of FINS, FPG, HbA1c, CRP, IL-6, IL-8, TNF-α, VCAM-1, ICAM-1 of the observa-tion group were significantly less than those of the control group ( t =3.915, t =2.494, t =1.929, t =6.187, t =3.611, t =6.356, t =4.182, t =7.505, t =1.879, P =0.000, P =0.007, P =0.028, P =0.000, P =0.012, P =0.000, P =0.000,P =0.000,P =0.032);Therewereheadache,ankleedema,facialflushing,coughandotheradversereactions occurred in both two groups, but there was no statistically significant between the two groups (χ2 =0.853,χ2 =0.443,χ2 =2.411,χ2 =2.411, P =0.356, P =0.506, P =0.120, P =0.12).Conclusion Telmisartan can through lowering blood glucose levels and improve insulin resistance , reduce inflammation , correct the abnormal state of adhesion molecules and other aspects of the treatment of hypertension with diabetes .
Keywords：TelmisartanHypertensionDiabetesInflammatory factorsAdhesion molecule
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1234-1237 )