Relationship between cystatin C and early atherosclerosis in patients with early atherosclerosis
DING Yuting
WANG Ancai
WANG Deguo
ZHANG Ying
ZHA Xiaojuan
HE Qinglan
PAN Shanshan
Abstract：Objective To observe the changes of serum cystatin C ( Cys C) level in patients with early atherosclero-sis,and investigate the potential clinical significance of Cys C level on diagnosis in patients with early atherosclerosis .Methods One hundred and twelve cases from September 2015 to January 2016 in Wangnan Medical College Affiliated Yijishan Hospi-tal were enrolled .Brachial ankle pulse wave velocity ( ba-PWV) of the subjects were measured to evaluate the extent of athero-sclerosis in patients with early stage .Automatic biochemical analyzer was used to detect the levels of the subject 's peripheral blood cystatin C (Cys C), uric acid (uric acid, UA),serum lipid and so on.Results (1) The cystatin C level in athero-sclerosis group was higher than that of non-atherosclerosis group[left:(1.05 ±0.18)mg/L vs.(0.97 ±0.16)mg/L, P <0.05;right:(1.04 ±0.17)mg/L vs.(0.97 ±0.17)mg/L, P <0.05].The age, BMI and total cholesterol (TC), LDL-C in atherosclerosis group compared with that of control group ,the difference was statistically significant ( P <0.05).However, the TG,high density lipoprotein ( HDL-C) ,BS and uric acid ( UA) level in atherosclerosis group compared with that of non-ather-osclerosis group, there is no significant difference ( P >0.05).Compared with the control group , the age, BMI, TC, TG of the two groups were statistically different ( t =-4.497,-2.781,-2.644,-2.319, P <0.05) , but there was no signifi-cant difference between BS,HDL-C, LDL-C and UA ( P >0.05).(2) There was a positive correlation between Cys C and age, TC and TG in arteriosclerosis index , and there was no significant correlation with age ( r =0.358, 0.225, 0.257, P <0.01).Conclusion The level of Cys C in the atherosclerosis group was higher than that in the control group , and was posi-tively correlated with the total cholesterol and the age of three .Cys C level has a certain clinical significance for early diagnosis of atherosclerosis in patients with early atherosclerosis .
Keywords：Cystatin CBrachial ankle pulse wave velocitySerum lipidEarly atherosclerosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1224-1227 )