SPAN-100 score combining inflammatory marker inpredicting risk of symptomatic intracerebral hemorrhage f ollow-ing intravenous thrombolysis treatment in acute ischemic stroke
WEI Heng
YIN Hongxiang
ZHOU Rui
GUO Zhenli
Abstract：Objective To assess the ability of SPAN-100 score combining hs-CRP level in predicting risk of symp-tomatic intracerebral hemorrhage ( sICH) following the recombinant tissue plasminogen activator ( rtP-A) intravenous throm-bolysis (IVT) treatment in acute ischemic stroke (AIS) patients.Methods Ninety-three cases of AIS patients within 4 .5h of stroke onset who were treated in Department of Neurology , Hubei provincial Hospital of Integrated Chinese&Western Medi-cine between May 1st, 2012 to March 1st, 2016 were enrolled.According to the head CT or MR and the change of NIHSS score,they were divided in sICH group and non-sICH group.Univariate analysis was used to assess the differences of SPAN-100 score, hs-CRP and risk factors for cerebrovascular disease between sICH group and non -sICH group.Further, univariate and multivariate logistic regression analysis were used to assess the independent predicted factors affecting sICH .Receiver op-erating characteristic ( ROC) curve analysis and calculation of the area under the curve ( AUC) were applied to evaluate the performance of SPAN-100 score, hs-CRP level and SPAN-100 combined with hs-CRP level in predicting sICH .Results Uni-variate analysis of baseline data:the sICH group age( t =2.766, P =0.007), NIHSS score before IVT( t =3.679, P =0.000), systolic blood pressure before IVT( t =3.613, P =0.004), hs-CRP level( t =2.305, P =0.023)and SPAN-100 positive(χ2 =19.079, P =0.000)were higher than non-sICH group, all differences had statistical significances (all P <0.05).Univariate Pearson correlation analysis showed elderly age , high NIHSS score before IVT, high systolic blood pressure before IVT, high hs-CRP level and SPAN-100 positive had positive correlation of sICH ( r =0.278, r =0.360, r =0.248, r =0 L.235, r =0.453, all P <0.05).Take above factors to multivariate logistic regression analysis showed that elderly age (OR=1.171,95%CI 1.018-1.346),elevated hs-CRP level (OR=1.258, 95%CI 1.032-1.533) and SPAN-100 posi-tive (OR=9.729, 95%CI 1.386-68.277) were the independent prediction factors for risk of sICH .ROC curve analysis showed AUC (SPAN-100)=0.726 (95%CI 0.503-0.950), AUC (hs-CRP level) =0.711 (95%CI 0.501-0.921) and AUC (SPA-100 +hs-CRP level) =0.768 (95%CI 0.548-0.989), all P <0.05.Conclusion It demonstrated that the SPAN-100 score was a simple , easy to calculate and effective predictive sICH tools , combined with CRP HS detection can sig-nificantly improve the predictive value of sICH .
Keywords：SPAN-100 scoreHigh sensitivity C reactive proteinIntravenous thromblysisSymptomatic intracerebral hemorrhage
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1219-1223 )