Clinical efficacy and changes in TNF-α,IL-8,PCT of children with acute bacterial enteritis in treatment with different types of cephalosporins

XUE Yan; LIN Lijuan; SHAO Tian; ZHAO Ying; DU Jinghui

doi:10.3969/j.issn.1671-6450.2016.11.020

Abstract：Objective To compare the clinical efficacy of cefixime and cefaclor in treatment of children with acute bacterial enteritis and effects of TNF alpha, IL-8,PCT.Methods Eighty-six cases of children with acute bacterial enteritis were selected, which were treated in hospital from February 2015 to February 2016, and they were divided into the A group (43 cases) and B group (43 cases).The patients of two groups were all treated with conventional treatment, basic nutrition support, maintain acid base balance, and correct electrolyte imbalance, and antiemetic, correct dehydration, rehydration and other symptomatic treatment.On the basis of basis treatment, the patients of the A group were treated with cefixime 2 mg/kg, twice a day,while the patients of B group were treated with cefaclor 10 mg/kg,twice a day.The patients of two groups were all continuing oral administration of 3-5 d after normal stool and a course of which were 7d.The ineffective patients replacement of antibiotics after treatment of 3d, it was not applied to other anti-diarrheal drugs or other antibiotics during treatment.When the children had symptom of high fever, using antipyretic for treatment, and when children had severe symptoms, intravenous in-fusion of electrolyte solution for treatment.Compare the clinical efficacy, improvement of clinical symptoms, the incidence of adverse reactions, and changes of the levels of TNF-α, IL-8, PCT of two groups.Results The total efficiency of the observa-tion group was 90.7%, higher than 72.1% in the control group (χ2 =4.914, P =0.027); compared with before treatment, serum TNF-α, IL-8, lower the level of PCT in 2 groups after treatment, and the observation group than the control group de-creased significantly ( t =13.946, t =4.745, t =5.298, P <0.05), the observation group stool frequency normal time, stool recovery time, cooling time, hospitalization time was significantly shorter than the control group, the stool negative rate was significantly higher than the control group ( t /χ2 =24.384,20.603,22.172,9.716,22.216, P <0.05);the 2 groups in the process of occurrence of allergic dermatitis,drug rash,changes in sleep and blood the reaction and other adverse symptoms, but the difference was not statistically significant(χ2 =1.625,χ2 =1.316,χ2 =0.443,χ2 =1.625, P >0.05).Conclusion The clinical efficacy of cefixime in the treatment of patients with acute bacterial enteritis is better than cefaclor,can effectively control the serum inflammatory index,relieve symptoms,high safety,is conducive to the prognosis of patients,worthy of clinical application.