Changes in cellular immune and inflammatory factors of children with bronchial asthma in treatment with bronchov-axom capsule

LV Yanqing; ZHAN Ping; GU Hongmei; LIU Faying; WANG Bangyun

doi:10.3969/j.issn.1671-6450.2016.11.019

Abstract：Objective To analyze the bronchovaxom capsule in the treatment of children bronchial asthma curative effect and effect on cell immune and inflammatory factor levels.Methods One hundred and sixteen cases of children with bronchial asthma were enrolled, which were treated in hospital from January 2015 to January 2016, and were divided into the observation group (58 cases) and control group (58 cases).The patients of two groups were all treated with conventional treatment, including antibiotics, antispasmodic and so on.The patients of control group were treated with budesonide.On the basis of control group, the patients of observation group were treated with bronchovaxom capsule.The children of two groups were all treated for consecutive 3 courses.Observe and compare the clinic results and changes of pulmonary function, cellular immune and inflammatory factors of two groups.Results The total efficiency of the observation group was 91.4%, higher than 72.4% in the control group (χ2 =7.036, P =0.008).Compared with before treatment, 2 groups of PEF, FEV1 , CD3+, CD4+, CD4+/CD8+, IFN-γwere increased ( t observation group =5.951, t observation group =8.653, t observa-tion group =22.817, t observation group =30.252, t observation group =10.561, t observation group =25.015, P <0.05;t control group =3.739, t control group =4.157, t control group =7.483, t control group =11.610, t control group =10.218, t control group =10.316, P <0.05), CD8+, IL-4 were decreased ( t observation group =21.327, t observation group =40.581, P <0.05; t control group =6.655, t control group =18.065, P <0.05), and the observation group is more obvious ( t =2.331, t =3.266, t =12.756, t =14.970, t =6.812, t =16.077, t =17.546, t =25.408, P <0.05).Conclusion Broncho vaxom capsule used in the treatment of children with bronchial asthma, can improve the clinical effect of patients, reduce the levels of inflammatory factors, improve immune function, has important clinical significance.