The effect of etomidate and propofol by targeting controlled infusion on function of adrenal cortex and adverse reac-tion in patients with general anesthesia:a systematic review
LIU Lian
XIA Zhongyuan
CHEN Rong
ZHAO Bo
LENG Yan
Abstract：Objective To evaluate the effect of etomidate and propofolby targeting controlled infusion on the function of adrenal cortex and the adverse reaction systematically in patients with general anesthesia.Methods An extensive search was performed within The Cochrane library, PubMed, MEDLINE, EMBASE, Wanfang Data, CINK, VIP for the randomized controlled trials (RCTs).The retrieval time was from the database established to March 2016.The included studies were e-valuated strictly and the extracted data were analyzed by RevMan 5.2.Results 11 RCTs were included, containing a total of 834 patients.Analysis results demonstrated that the function of adrenal cortex in the etomidate group were significantly lower than the propofol group at the end of the operation ( MD=-161.54,95%CI -233.14~-89.94, P <0.01) , however, af-ter 24h, the function of adrenal cortex of the two groups showed no differences ( MD=4.73,95%CI -0.81~10.26, P =0.29).Whereas the incidence of the adverse reactions (nausea and vomiting, muscle tremors, postoperative agitation) in eto-midate group were higher than that in propofol group, significantly ( MD=3.16,95%CI 1.47 ~6.82, P =0.003;MD=5.54,95%CI 1.18~25.99, P =0.03;MD=7.26,95%CI 3.48~15.12, P <0.01).Conclusion Inhibitory effect of eto-midate on adrenocortical function is transient and reversible, but etomidate caused more adverse reactions than propofol.
Keywords：Target controlled infusionEtomidatePropofolAdrenal cortexAdverse reactionMeta analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1069-1073 )